TY - JOUR
T1 - Nuclear receptors in regenerating liver and hepatocellular carcinoma
AU - Vacca, Michele
AU - Degirolamo, Chiara
AU - Massafra, Vittoria
AU - Polimeno, Lorenzo
AU - Mariani-Costantini, Renato
AU - Palasciano, Giuseppe
AU - Moschetta, Antonio
N1 - Funding Information:
The authors are indebted to Dr. C. Gardmo and Dr. S. D’Amore for critically reading the manuscript. M. Vacca was a fellow of the G. D’Annunzio University Ph.D. Oncology program. Grant support: The work was funded by Italian Association for Cancer Research (AIRC, Milan, Italy, IG 10416 to A.M. and IG 9168 to R.M.C.), Italian Ministry of Health and Education (Finanziamenti per la Ricerca di Base IDEAS RBID08C9N7), Italian Ministry of Health (Young Researchers Grant 2008, GR-2008-1143546), University of Bari, Italy (ORBA 08WEZJ, 07X7Q1, 06BXVC, IDEA GRBA0802SJ), Fondazione Caripuglia (IRCCS De Bellis Castellana Grotte), CariSPAQ (L’Aquila, Italy).
PY - 2013/4/10
Y1 - 2013/4/10
N2 - A comprehensive understanding of the pathways underlying hepatocyte turnover and liver regeneration is essential for the development of innovative and effective therapies in the management of chronic liver disease, and the prevention of hepatocellular carcinoma (HCC) in cirrhosis. Nuclear receptors (NRs) are master transcriptional regulators of liver development, differentiation and function. NRs have been implicated in the modulation of hepatocyte priming and proliferation in regenerating liver, chronic hepatitis and HCC development. In this review, we focus on NRs and their pathways regulating hepatocyte proliferation and liver regeneration, with a perspective view on NRs as candidate biomarkers and novel pharmacological targets in the management of liver disease and HCC.
AB - A comprehensive understanding of the pathways underlying hepatocyte turnover and liver regeneration is essential for the development of innovative and effective therapies in the management of chronic liver disease, and the prevention of hepatocellular carcinoma (HCC) in cirrhosis. Nuclear receptors (NRs) are master transcriptional regulators of liver development, differentiation and function. NRs have been implicated in the modulation of hepatocyte priming and proliferation in regenerating liver, chronic hepatitis and HCC development. In this review, we focus on NRs and their pathways regulating hepatocyte proliferation and liver regeneration, with a perspective view on NRs as candidate biomarkers and novel pharmacological targets in the management of liver disease and HCC.
KW - Liver
KW - Molecular biology
KW - Nuclear receptors
UR - http://www.scopus.com/inward/record.url?scp=84875245371&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84875245371&partnerID=8YFLogxK
U2 - 10.1016/j.mce.2012.06.025
DO - 10.1016/j.mce.2012.06.025
M3 - Review article
C2 - 22789748
AN - SCOPUS:84875245371
SN - 0303-7207
VL - 368
SP - 108
EP - 119
JO - Molecular and Cellular Endocrinology
JF - Molecular and Cellular Endocrinology
IS - 1-2
ER -