Abstract
Both primary and transformed cells need cholesterol for their growth. Guo and colleagues unraveled the connection between epidermal growth factor receptor mutations in glioblastoma and increased cholesterol influx via sterol regulatory element-binding protein 1 and low-density lipoprotein receptor (LDLR) increase. They propose the activation of the liver X receptor-inducible degrader of LDLR-LDLR axis as a therapeutic approach to reduce intracellular cholesterol, block tumor growth, and induce cell death.
Original language | English (US) |
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Pages (from-to) | 381-382 |
Number of pages | 2 |
Journal | Cancer discovery |
Volume | 1 |
Issue number | 5 |
DOIs | |
State | Published - Oct 2011 |
ASJC Scopus subject areas
- Oncology