Abstract
OBJECTIVE: To examine the hypothesis that nuclear factor-B (NF-B), a transcription factor involved in anti-apoptosis, invasion, and angiogenesis, plays a role in the carcinogenesis of upper urinary tract urothelial carcinoma (UUT-UC) and has prognostic value for survival. PATIENTS AND METHODS: In all, 90 patients with UUT-UC [mean (range) age, 64.5 (24-84) years] who underwent surgery at our institution from January 1991 to December 2005 were included. Clinicopathological data were collected retrospectively. We performed immunohistochemical staining for NF-B (p65) on paraffin-embedded sections of the tumour and corresponding normal tissues. The association between survival and potential prognostic factors was examined. RESULTS: The median follow-up was 40 months. In all, 55 patients (61.1%) with UUT-UC overexpressed cytoplasmic NF-B, and nuclear immunoreactivity for NF-B was detected in 24 patients (26.7%). On univariate analysis, significant prognostic factors for survival were tumour location, stage, grade, lymph node involvement, and nuclear NF-B expression. On multivariate analysis, nuclear NF-B positivity was an independent predictor for disease-specific survival [Cox regression hazard ratio (HR) 2.87; P = 0.025] and overall survival (HR 2.24; P = 0.037). CONCLUSION: These results imply a role for nuclear NF-B expression in the tumorigenesis of UUT-UC. Nuclear NF-B may serve as a useful independent molecular marker to predict outcome and may represent a promising therapeutic target for patients with UUT-UC.
Original language | English (US) |
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Pages (from-to) | 1223-1229 |
Number of pages | 7 |
Journal | BJU international |
Volume | 106 |
Issue number | 8 |
DOIs | |
State | Published - Oct 2010 |
Externally published | Yes |
Keywords
- NF-B
- immunohistochemistry
- p65
- prognosis
- upper urinary tract
- urothelial carcinoma
ASJC Scopus subject areas
- Urology