NPAS4 juggles neuronal activity-dependent transcription and DSB repair with NuA4

Ilse Delint-Ramirez; Ram Madabhushi

doi:10.1016/j.molcel.2023.03.019

NPAS4 juggles neuronal activity-dependent transcription and DSB repair with NuA4

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

In a recent study, Pollina et al.¹ discover a new neuron-specific NuA4-TIP60 chromatin remodeling complex that facilitates the repair of activity-induced DNA double-strand breaks (DSBs) in neurons and protects against mutations that accumulate with age and early death.

Original language	English (US)
Pages (from-to)	1208-1209
Number of pages	2
Journal	Molecular cell
Volume	83
Issue number	8
DOIs	https://doi.org/10.1016/j.molcel.2023.03.019
State	Published - Apr 20 2023

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1016/j.molcel.2023.03.019

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@article{cb32d983c6374a168699825ad2afc7d3,

title = "NPAS4 juggles neuronal activity-dependent transcription and DSB repair with NuA4",

abstract = "In a recent study, Pollina et al.1 discover a new neuron-specific NuA4-TIP60 chromatin remodeling complex that facilitates the repair of activity-induced DNA double-strand breaks (DSBs) in neurons and protects against mutations that accumulate with age and early death.",

author = "Ilse Delint-Ramirez and Ram Madabhushi",

note = "Funding Information: This work is supported by NIMH R01-MH120132 to R.M. Publisher Copyright: {\textcopyright} 2023 Elsevier Inc.",

year = "2023",

month = apr,

day = "20",

doi = "10.1016/j.molcel.2023.03.019",

language = "English (US)",

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journal = "Molecular cell",

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publisher = "Cell Press",

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T1 - NPAS4 juggles neuronal activity-dependent transcription and DSB repair with NuA4

AU - Delint-Ramirez, Ilse

AU - Madabhushi, Ram

PY - 2023/4/20

Y1 - 2023/4/20

N2 - In a recent study, Pollina et al.1 discover a new neuron-specific NuA4-TIP60 chromatin remodeling complex that facilitates the repair of activity-induced DNA double-strand breaks (DSBs) in neurons and protects against mutations that accumulate with age and early death.

AB - In a recent study, Pollina et al.1 discover a new neuron-specific NuA4-TIP60 chromatin remodeling complex that facilitates the repair of activity-induced DNA double-strand breaks (DSBs) in neurons and protects against mutations that accumulate with age and early death.

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DO - 10.1016/j.molcel.2023.03.019

M3 - Comment/debate

C2 - 37084713

AN - SCOPUS:85152466587

SN - 1097-2765

VL - 83

SP - 1208

EP - 1209

JO - Molecular cell

JF - Molecular cell

IS - 8

ER -

NPAS4 juggles neuronal activity-dependent transcription and DSB repair with NuA4

Abstract

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