TY - JOUR
T1 - Novel epoxides formed during the liver cytochrome P-450 oxidation of arachidonic acid
AU - Chacos, N.
AU - Falck, J R
AU - Wixtrom, C.
AU - Capdevila, J.
PY - 1982/2/11
Y1 - 1982/2/11
N2 - Arachidonic acid is enzymatically oxidized by the rat liver microsomal mixed-function oxidase system, in the presence of NADPH and oxygen, to a wide variety of products. We report here, the identification of the major organic-soluble metabolites. They are the 5,6-,8,9-,11,12-, and 14,15-epoxy-eicosatrienoic acid derivatives of arachidonic acid.
AB - Arachidonic acid is enzymatically oxidized by the rat liver microsomal mixed-function oxidase system, in the presence of NADPH and oxygen, to a wide variety of products. We report here, the identification of the major organic-soluble metabolites. They are the 5,6-,8,9-,11,12-, and 14,15-epoxy-eicosatrienoic acid derivatives of arachidonic acid.
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U2 - 10.1016/0006-291X(82)91336-5
DO - 10.1016/0006-291X(82)91336-5
M3 - Article
C2 - 6803794
AN - SCOPUS:0020058195
SN - 0006-291X
VL - 104
SP - 916
EP - 922
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 3
ER -