Novel biomarker candidates for colorectal cancer metastasis: A meta-analysis of in vitro studies

Nguyen Phuoc Long; Wun Jun Lee; Nguyen Truong Huy; Seul Ji Lee; Jeong Hill Park; Sung Won Kwon

doi:10.4137/CIN.S40301

Novel biomarker candidates for colorectal cancer metastasis: A meta-analysis of in vitro studies

Nguyen Phuoc Long, Wun Jun Lee, Nguyen Truong Huy, Seul Ji Lee, Jeong Hill Park, Sung Won Kwon

Physiology

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Colorectal cancer (CRC) is one of the most common and lethal cancers. Although numerous studies have evaluated potential biomarkers for early diagnosis, current biomarkers have failed to reach an acceptable level of accuracy for distant metastasis. In this paper, we performed a gene set meta-analysis of in vitro microarray studies and combined the results from this study with previously published proteomic data to validate and suggest prog-nostic candidates for CRC metastasis. Two microarray data sets included found 21 significant genes. Of these significant genes, ALDOA, IL8 (CXCL8), and PARP4 had strong potential as prognostic candidates. LAMB2, MCM7, CXCL23A, SERPINA3, ABCA3, ALDH3A2, and POLR2I also have potential. Other candidates were more controversial, possibly because of the biologic heterogeneity of tumor cells, which is a major obstacle to predicting metastasis. In conclusion, we demonstrated a meta-analysis approach and successfully suggested ten biomarker candidates for future investigation.

Original language	English (US)
Pages (from-to)	11-17
Number of pages	7
Journal	Cancer Informatics
Volume	15
DOIs	https://doi.org/10.4137/CIN.S40301
State	Published - Sep 22 2016

Keywords

Biomarker candidate
Colorectal cancer
Microarray analysis
Proteomics

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "Novel biomarker candidates for colorectal cancer metastasis: A meta-analysis of in vitro studies",

abstract = "Colorectal cancer (CRC) is one of the most common and lethal cancers. Although numerous studies have evaluated potential biomarkers for early diagnosis, current biomarkers have failed to reach an acceptable level of accuracy for distant metastasis. In this paper, we performed a gene set meta-analysis of in vitro microarray studies and combined the results from this study with previously published proteomic data to validate and suggest prog-nostic candidates for CRC metastasis. Two microarray data sets included found 21 significant genes. Of these significant genes, ALDOA, IL8 (CXCL8), and PARP4 had strong potential as prognostic candidates. LAMB2, MCM7, CXCL23A, SERPINA3, ABCA3, ALDH3A2, and POLR2I also have potential. Other candidates were more controversial, possibly because of the biologic heterogeneity of tumor cells, which is a major obstacle to predicting metastasis. In conclusion, we demonstrated a meta-analysis approach and successfully suggested ten biomarker candidates for future investigation.",

keywords = "Biomarker candidate, Colorectal cancer, Microarray analysis, Proteomics",

author = "Long, {Nguyen Phuoc} and Lee, {Wun Jun} and Huy, {Nguyen Truong} and Lee, {Seul Ji} and Park, {Jeong Hill} and Kwon, {Sung Won}",

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doi = "10.4137/CIN.S40301",

language = "English (US)",

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T1 - Novel biomarker candidates for colorectal cancer metastasis

T2 - A meta-analysis of in vitro studies

AU - Long, Nguyen Phuoc

AU - Lee, Wun Jun

AU - Huy, Nguyen Truong

AU - Lee, Seul Ji

AU - Park, Jeong Hill

AU - Kwon, Sung Won

N1 - Publisher Copyright: © the authors, publisher and licensee Libertas Academica Limited.

PY - 2016/9/22

Y1 - 2016/9/22

N2 - Colorectal cancer (CRC) is one of the most common and lethal cancers. Although numerous studies have evaluated potential biomarkers for early diagnosis, current biomarkers have failed to reach an acceptable level of accuracy for distant metastasis. In this paper, we performed a gene set meta-analysis of in vitro microarray studies and combined the results from this study with previously published proteomic data to validate and suggest prog-nostic candidates for CRC metastasis. Two microarray data sets included found 21 significant genes. Of these significant genes, ALDOA, IL8 (CXCL8), and PARP4 had strong potential as prognostic candidates. LAMB2, MCM7, CXCL23A, SERPINA3, ABCA3, ALDH3A2, and POLR2I also have potential. Other candidates were more controversial, possibly because of the biologic heterogeneity of tumor cells, which is a major obstacle to predicting metastasis. In conclusion, we demonstrated a meta-analysis approach and successfully suggested ten biomarker candidates for future investigation.

AB - Colorectal cancer (CRC) is one of the most common and lethal cancers. Although numerous studies have evaluated potential biomarkers for early diagnosis, current biomarkers have failed to reach an acceptable level of accuracy for distant metastasis. In this paper, we performed a gene set meta-analysis of in vitro microarray studies and combined the results from this study with previously published proteomic data to validate and suggest prog-nostic candidates for CRC metastasis. Two microarray data sets included found 21 significant genes. Of these significant genes, ALDOA, IL8 (CXCL8), and PARP4 had strong potential as prognostic candidates. LAMB2, MCM7, CXCL23A, SERPINA3, ABCA3, ALDH3A2, and POLR2I also have potential. Other candidates were more controversial, possibly because of the biologic heterogeneity of tumor cells, which is a major obstacle to predicting metastasis. In conclusion, we demonstrated a meta-analysis approach and successfully suggested ten biomarker candidates for future investigation.

KW - Biomarker candidate

KW - Colorectal cancer

KW - Microarray analysis

KW - Proteomics

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Novel biomarker candidates for colorectal cancer metastasis: A meta-analysis of in vitro studies

Abstract

Keywords

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