Novel amphiphilic α-helix mimetics based on a bis-benzamide scaffold

Srinivasa Marimgantl, Murthy N. Cheemala, Jung Mo Ahn

Research output: Contribution to journalArticlepeer-review

75 Scopus citations


To mimic amphophilic a-helices, a new scaffold was designed based on a bis-benzamide that places four side-chain functional groups found at the i, i+2, i+5, and i+7 positions of a helix. Its two hydrogen bonds fix the conformation and provide accurate bifacial arrangement of the four substituents, simultaneously representing two opposing helical sides. An efficient synthetic route was achieved for the construction of bis-benzamides, and their superior a-helix mimicry was confirmed by X-ray crystallography.

Original languageEnglish (US)
Pages (from-to)4418-4421
Number of pages4
JournalOrganic Letters
Issue number19
StatePublished - Oct 1 2009

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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