TY - JOUR
T1 - Not your Mother’s MAPKs
T2 - Apicomplexan MAPK function in daughter cell budding
AU - O’Shaughnessy, William J.
AU - Dewangan, Pravin S.
AU - Ariana Paiz, E.
AU - Reese, Michael L.
N1 - Publisher Copyright:
Copyright: © 2022 O’Shaughnessy et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2022/10
Y1 - 2022/10
N2 - AU Reversible: Pleaseconfirmthatallheadinglevelsarerepresentedcorrectly phosphorylation by protein kinases is one of the :core mechanisms by which biological signals are propagated and processed. Mitogen-activated protein kinases, or MAPKs, are conserved throughout eukaryotes where they regulate cell cycle, development, and stress response. Here, we review advances in our understanding of the function and biochemistry of MAPK signaling in apicomplexan parasites. As expected for well-conserved signaling modules, MAPKs have been found to have multiple essential roles regulating both Toxoplasma tachyzoite replication and sexual differentiation in Plasmodium. However, apicomplexan MAPK signaling is notable for the lack of the canonical kinase cascade that normally regulates the networks, and therefore must be regulated by a distinct mechanism. We highlight what few regulatory relationships have been established to date, and discuss the challenges to the field in elucidating the complete MAPK signaling networks in these parasites.
AB - AU Reversible: Pleaseconfirmthatallheadinglevelsarerepresentedcorrectly phosphorylation by protein kinases is one of the :core mechanisms by which biological signals are propagated and processed. Mitogen-activated protein kinases, or MAPKs, are conserved throughout eukaryotes where they regulate cell cycle, development, and stress response. Here, we review advances in our understanding of the function and biochemistry of MAPK signaling in apicomplexan parasites. As expected for well-conserved signaling modules, MAPKs have been found to have multiple essential roles regulating both Toxoplasma tachyzoite replication and sexual differentiation in Plasmodium. However, apicomplexan MAPK signaling is notable for the lack of the canonical kinase cascade that normally regulates the networks, and therefore must be regulated by a distinct mechanism. We highlight what few regulatory relationships have been established to date, and discuss the challenges to the field in elucidating the complete MAPK signaling networks in these parasites.
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U2 - 10.1371/journal.ppat.1010849
DO - 10.1371/journal.ppat.1010849
M3 - Review article
C2 - 36227859
AN - SCOPUS:85139880513
SN - 1553-7366
VL - 18
JO - PLoS pathogens
JF - PLoS pathogens
IS - 10
M1 - e1010849
ER -