Norepinephrine stimulated increase of cyclic AMP levels in developing mouse brain cell cultures

Nicholas W. Seeds; Alfred G. Gilman

doi:10.1126/science.174.4006.292

Norepinephrine stimulated increase of cyclic AMP levels in developing mouse brain cell cultures

Nicholas W. Seeds, Alfred G. Gilman

Pharmacology

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Norepinephrine causes a four- to sixfold increase in the intracellular level of cyclic AMP (adenosine 3′,5′-monophosphate) reaggregated brain cell cultures derived from embryonic mouse brain. The cyclic AMP level of adult brain is increased by norepinephrine; however, embryonic mouse brain does not show a cyclic AMP response. The aggregate cultures thus demonstrate an event of differentiation very similar to that seen in vivo.

Original language	English (US)
Number of pages	1
Journal	Science
Volume	174
Issue number	4006
DOIs	https://doi.org/10.1126/science.174.4006.292
State	Published - Jan 1 1971

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title = "Norepinephrine stimulated increase of cyclic AMP levels in developing mouse brain cell cultures",

abstract = "Norepinephrine causes a four- to sixfold increase in the intracellular level of cyclic AMP (adenosine 3′,5′-monophosphate) reaggregated brain cell cultures derived from embryonic mouse brain. The cyclic AMP level of adult brain is increased by norepinephrine; however, embryonic mouse brain does not show a cyclic AMP response. The aggregate cultures thus demonstrate an event of differentiation very similar to that seen in vivo.",

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Norepinephrine stimulated increase of cyclic AMP levels in developing mouse brain cell cultures

Abstract

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