Nonsquamous Lesions of the Nasal Cavity, Paranasal Sinuses, and Nasopharynx

Alessandro Franchi, Justin A. Bishop

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


The nasal cavities, paranasal sinuses, and nasopharynx form the top of the upper respiratory tract and are located immediately beneath the base of the cranium, in close relationship with vital structures. This complex anatomic region is very much exposed to airborne agents and hosts a variety of often rare inflammatory and neoplastic conditions, which represent a diagnostic challenge for the surgical pathologist. The contents of this chapter cover inflammatory disorders, including infectious and noninfectious diseases, non-neoplastic lesions, including cysts and hamartoma, as well as benign, borderline, and malignant neoplasms. Among the neoplasms, emphasis is made on those entities characteristic or even unique for these regions, such as sinonasal papillomas, glomangiopericytoma, intestinal and nonintestinal type adenocarcinomas, nasopharyngeal papillary adenocarcinoma, olfactory neuroblastoma, nasal-type N/K T-cell lymphoma, and teratocarcinosarcoma. Moreover, recently recognized entities such as HPV-related multiphenotypic sinonasal carcinoma, NUT carcinoma, SMARCB1-deficient carcinoma, and adamantinoma-like Ewing sarcoma are also discussed in the light of their specific molecular findings. The text is accompanied by an updated reference list, tables summarizing the key features of selected tumors aiming to help in their differential diagnosis, and more than 70 illustrations.

Original languageEnglish (US)
Title of host publicationGnepp's Diagnostic Surgical Pathology of the Head and Neck, Third Edition
Number of pages62
ISBN (Electronic)9780323531146
ISBN (Print)9780323547819
StatePublished - Jan 1 2020


  • benign tumors
  • borderline tumors
  • fungal diseases, polyp
  • infection
  • inflammatory disorders
  • malignant tumors
  • nasal cavity
  • nasopharynx
  • paranasal sinuses
  • pseudotumors

ASJC Scopus subject areas

  • Medicine(all)


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