TY - JOUR
T1 - Nonserious Infections. Should There Be Cause for Serious Concerns?
AU - Dao, Kathryn H.
AU - Herbert, Morley
AU - Habal, Nadia
AU - Cush, John J.
PY - 2012/11
Y1 - 2012/11
N2 - Nonserious infections (NSIE) as colds, flu syndromes, and urinary tract infection, are the most common infections seen in patients with immune mediated inflammatory diseases. Yet, little is known about the impact of immunosuppression, particularly with tumor necrosis factor inhibitors (TNFi), on these infections. A systemic review of large, randomized controlled trials was conducted to identify incidence, types, and outcomes of NSIE associated with the most commonly prescribed TNFi: adalimumab, etanercept, and infliximab.
AB - Nonserious infections (NSIE) as colds, flu syndromes, and urinary tract infection, are the most common infections seen in patients with immune mediated inflammatory diseases. Yet, little is known about the impact of immunosuppression, particularly with tumor necrosis factor inhibitors (TNFi), on these infections. A systemic review of large, randomized controlled trials was conducted to identify incidence, types, and outcomes of NSIE associated with the most commonly prescribed TNFi: adalimumab, etanercept, and infliximab.
KW - Adalimumab
KW - Anti-TNF
KW - Etanercept
KW - Infliximab
KW - Nonserious infections
KW - Rheumatoid arthritis
KW - Safety
UR - http://www.scopus.com/inward/record.url?scp=84868357446&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84868357446&partnerID=8YFLogxK
U2 - 10.1016/j.rdc.2012.08.016
DO - 10.1016/j.rdc.2012.08.016
M3 - Review article
C2 - 23137578
AN - SCOPUS:84868357446
SN - 0889-857X
VL - 38
SP - 707
EP - 725
JO - Rheumatic Disease Clinics of North America
JF - Rheumatic Disease Clinics of North America
IS - 4
ER -