TY - JOUR
T1 - Non-relapse mortality in pediatric acute lymphoblastic leukemia
T2 - A systematic review and meta-analysis
AU - Blanco, Esther
AU - Beyene, Joseph
AU - Maloney, Anne Marie
AU - Almeida, Rowena
AU - Ethier, Marie Chantal
AU - Winick, Naomi
AU - Alexander, Sarah
AU - Sung, Lillian
N1 - Funding Information:
We wish to thank Elizabeth Uleryk for her tremendous support in conducting the literature search. L.S. is supported by a New Investigator Award from the Canadian Institutes of Health Research.
PY - 2012/5
Y1 - 2012/5
N2 - The primary objective of the study was to describe non-relapse mortality (NRM) and the proportion of first events that are deaths in children with acute lymphoblastic leukemia (ALL). Secondary objectives were to identify groups at higher risk and to determine whether proportions have changed over time. We performed a systematic review of randomized pediatric ALL studies. From 1337 articles, 59 were included, comprising a total of 49 071 patients. The induction death rate was 1.38%, remission death rate was 1.94% and total NRM was 3.60%. Deaths were responsible for 53.84% of first events during induction and 13.03% in total. Standard risk patients had significantly lower NRM during remission. The year of study was not associated with NRM. The results of the study show that the rate of NRM in children with ALL is 3.60% and those with high risk ALL have significantly higher NRM during remission, but NRM has not changed over time. Future research should focus on the exploration of patient-related risk factors for NRM.
AB - The primary objective of the study was to describe non-relapse mortality (NRM) and the proportion of first events that are deaths in children with acute lymphoblastic leukemia (ALL). Secondary objectives were to identify groups at higher risk and to determine whether proportions have changed over time. We performed a systematic review of randomized pediatric ALL studies. From 1337 articles, 59 were included, comprising a total of 49 071 patients. The induction death rate was 1.38%, remission death rate was 1.94% and total NRM was 3.60%. Deaths were responsible for 53.84% of first events during induction and 13.03% in total. Standard risk patients had significantly lower NRM during remission. The year of study was not associated with NRM. The results of the study show that the rate of NRM in children with ALL is 3.60% and those with high risk ALL have significantly higher NRM during remission, but NRM has not changed over time. Future research should focus on the exploration of patient-related risk factors for NRM.
KW - Acute lymphoblastic leukemia
KW - non-relapse mortality
KW - pediatrics
KW - risk factors
KW - treatment-related mortality
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U2 - 10.3109/10428194.2011.639018
DO - 10.3109/10428194.2011.639018
M3 - Review article
C2 - 22066711
AN - SCOPUS:84859940348
SN - 1042-8194
VL - 53
SP - 878
EP - 885
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 5
ER -