Ever since it was shown that the 19F NMR spin-lattice relaxation rates (Ri) of perfluorocarbon (PFC) emulsions are highly sensitive to oxygen tension (p02), there has been a developing interest in the use of PFCs to probe tissue physiology. Oxygen is required for efficient function by most tissues and hypoxia leads to rapid cellular dysfunction and damage. In addition, hypoxic tumor cells are refractory to radiotherapy. Thus, the opportunity to measure tissue oxygen tension noninvasively may be significant in understanding mechanisms of tissue function and in clinical prognosis. PFC NMR parameters are also sensitive to temperature, facilitating NMR thermometry with potential applications in hyperthermia studies. I will review the development of experimental techniques, applications to specific tissues and discuss the challenges and opportunities presented by 19F NMR of perfluorocarbons.
|Original language||English (US)|
|Number of pages||13|
|Journal||Artificial Cells, Blood Substitutes, and Biotechnology|
|State||Published - Jan 1994|
ASJC Scopus subject areas
- Biomedical Engineering