Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)

Amy G. Zhou; Justin A. Bishop; Syed Z. Ali

doi:10.1016/j.jasc.2017.06.206

Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)

Amy G. Zhou, Justin A. Bishop, Syed Z. Ali

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is a new term replacing what was previously known as non-invasive encapsulated follicular variant of papillary thyroid carcinoma (FVPTC). These tumors show benign/indolent clinical behavior when compared with invasive FVPTC, which led to their reclassification as a “non-malignant” neoplasm. NIFTP shares essentially similar cytomorphologic features as FVPTC, and can only be definitively diagnosed on surgical excision specimens. This article provides an update on morphologic characteristics of NIFTP, along with pertinent molecular studies and management algorithms.

Original language	English (US)
Pages (from-to)	211-216
Number of pages	6
Journal	Journal of the American Society of Cytopathology
Volume	6
Issue number	5
DOIs	https://doi.org/10.1016/j.jasc.2017.06.206
State	Published - Sep 1 2017

Keywords

Afirma gene expression classifier
Follicular variant of papillary thyroid carcinoma (FVPTC)
Indeterminate thyroid nodules
Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)
Papillary thyroid carcinoma (PTC)
Thyroid fine needle aspiration (FNA)

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1016/j.jasc.2017.06.206

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title = "Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)",

abstract = "Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is a new term replacing what was previously known as non-invasive encapsulated follicular variant of papillary thyroid carcinoma (FVPTC). These tumors show benign/indolent clinical behavior when compared with invasive FVPTC, which led to their reclassification as a “non-malignant” neoplasm. NIFTP shares essentially similar cytomorphologic features as FVPTC, and can only be definitively diagnosed on surgical excision specimens. This article provides an update on morphologic characteristics of NIFTP, along with pertinent molecular studies and management algorithms.",

keywords = "Afirma gene expression classifier, Follicular variant of papillary thyroid carcinoma (FVPTC), Indeterminate thyroid nodules, Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP), Papillary thyroid carcinoma (PTC), Thyroid fine needle aspiration (FNA)",

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AU - Bishop, Justin A.

AU - Ali, Syed Z.

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N2 - Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is a new term replacing what was previously known as non-invasive encapsulated follicular variant of papillary thyroid carcinoma (FVPTC). These tumors show benign/indolent clinical behavior when compared with invasive FVPTC, which led to their reclassification as a “non-malignant” neoplasm. NIFTP shares essentially similar cytomorphologic features as FVPTC, and can only be definitively diagnosed on surgical excision specimens. This article provides an update on morphologic characteristics of NIFTP, along with pertinent molecular studies and management algorithms.

AB - Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is a new term replacing what was previously known as non-invasive encapsulated follicular variant of papillary thyroid carcinoma (FVPTC). These tumors show benign/indolent clinical behavior when compared with invasive FVPTC, which led to their reclassification as a “non-malignant” neoplasm. NIFTP shares essentially similar cytomorphologic features as FVPTC, and can only be definitively diagnosed on surgical excision specimens. This article provides an update on morphologic characteristics of NIFTP, along with pertinent molecular studies and management algorithms.

KW - Afirma gene expression classifier

KW - Follicular variant of papillary thyroid carcinoma (FVPTC)

KW - Indeterminate thyroid nodules

KW - Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)

KW - Papillary thyroid carcinoma (PTC)

KW - Thyroid fine needle aspiration (FNA)

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Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)

Abstract

Keywords

ASJC Scopus subject areas

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