Noise properties of low-dose X-ray CT sinogram data in Radon space

Jing Wang, Hongbing Lu, Zhengrong Liang, Daria Eremina, Guangxiang Zhang, Su Wang, John Chen, James Manzione

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations


Computed tomography (CT) has been well established as a diagnostic tool through hardware optimization and sophisticated data calibration. For screening purposes, the associated X-ray exposure risk must be minimized. An effective way to minimize the risk is to deliver fewer X-rays to the subject or lower the mAs parameter in data acquisition. This will increase the data noise. This work aims to study the noise property of the calibrated or preprocessed sinogram data in Radon space as the mAs level decreases. An anthropomorphic torso phantom was scanned repeatedly by a commercial CT imager at five different mAs levels from 100 down to 17 (the lowest value provided by the scanner). The preprocessed sinogram dataseis were extracted from the CT scanner to a laboratory computer for noise analysis. The repeated measurements at each mAs level were used to test the normality of the repeatedly measured samples for each data channel using the Shapiro-WiIk statistical test merit. We further studied the probability distribution of the repeated measures. Most importantly, we validated a theoretical relationship between the sample mean and variance at each channel. It is our intention that the statistical test and particularly the relationship between the first and second statistical moments will improve low-dose CT image reconstruction for screening applications.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2008 - Physics of Medical Imaging
StatePublished - 2008
EventMedical Imaging 2008 - Physics of Medical Imaging - San Diego, CA, United States
Duration: Feb 18 2008Feb 21 2008

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


OtherMedical Imaging 2008 - Physics of Medical Imaging
Country/TerritoryUnited States
CitySan Diego, CA


  • Low-dose CT
  • Noise reduction
  • Screening application
  • Sinogram data
  • Statistical moments

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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