No Driver behind the Wheel? Targeting Transcription in Cancer

Hector L. Franco; W. Lee Kraus

doi:10.1016/j.cell.2015.09.013

No Driver behind the Wheel? Targeting Transcription in Cancer

Hector L. Franco, W. Lee Kraus

Research output: Contribution to journal › Short survey › peer-review

25 Scopus citations

Abstract

Exploiting the dependence of cancer cells on transcription can be used as an effective strategy for targeting aggressive and therapeutically recalcitrant tumors. Wang et al. show that inhibiting transcription using THZ1, a small-molecule inhibitor of cyclin-dependent kinase CDK7, induces apoptotic cell death in triple-negative breast cancers.

Original language	English (US)
Pages (from-to)	28-30
Number of pages	3
Journal	Cell
Volume	163
Issue number	1
DOIs	https://doi.org/10.1016/j.cell.2015.09.013
State	Published - Sep 24 2015

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.cell.2015.09.013

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title = "No Driver behind the Wheel? Targeting Transcription in Cancer",

abstract = "Exploiting the dependence of cancer cells on transcription can be used as an effective strategy for targeting aggressive and therapeutically recalcitrant tumors. Wang et al. show that inhibiting transcription using THZ1, a small-molecule inhibitor of cyclin-dependent kinase CDK7, induces apoptotic cell death in triple-negative breast cancers.",

author = "Franco, {Hector L.} and Kraus, {W. Lee}",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",

year = "2015",

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doi = "10.1016/j.cell.2015.09.013",

language = "English (US)",

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T1 - No Driver behind the Wheel? Targeting Transcription in Cancer

AU - Franco, Hector L.

AU - Kraus, W. Lee

PY - 2015/9/24

Y1 - 2015/9/24

N2 - Exploiting the dependence of cancer cells on transcription can be used as an effective strategy for targeting aggressive and therapeutically recalcitrant tumors. Wang et al. show that inhibiting transcription using THZ1, a small-molecule inhibitor of cyclin-dependent kinase CDK7, induces apoptotic cell death in triple-negative breast cancers.

AB - Exploiting the dependence of cancer cells on transcription can be used as an effective strategy for targeting aggressive and therapeutically recalcitrant tumors. Wang et al. show that inhibiting transcription using THZ1, a small-molecule inhibitor of cyclin-dependent kinase CDK7, induces apoptotic cell death in triple-negative breast cancers.

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VL - 163

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JO - Cell

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No Driver behind the Wheel? Targeting Transcription in Cancer

Abstract

ASJC Scopus subject areas

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