No Driver behind the Wheel? Targeting Transcription in Cancer

Hector L. Franco, W. Lee Kraus

Research output: Contribution to journalShort surveypeer-review

23 Scopus citations


Exploiting the dependence of cancer cells on transcription can be used as an effective strategy for targeting aggressive and therapeutically recalcitrant tumors. Wang et al. show that inhibiting transcription using THZ1, a small-molecule inhibitor of cyclin-dependent kinase CDK7, induces apoptotic cell death in triple-negative breast cancers.

Original languageEnglish (US)
Pages (from-to)28-30
Number of pages3
Issue number1
StatePublished - Sep 24 2015

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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