Nitrous oxide analgesia: partial antagonism by naloxone and total reversal after periaqueductal gray lesions in the rat

John R Zuniga; Shirley Joseph; Karl Knigge

doi:10.1016/0014-2999(87)90653-4

Nitrous oxide analgesia: partial antagonism by naloxone and total reversal after periaqueductal gray lesions in the rat

John R Zuniga, Shirley Joseph, Karl Knigge

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Analgesia induced by nitrous oxide was examined using radiant heat tail flick and electrical evoked foot flick tests in rats. Rats exposed to 80 and 60% nitrous oxide expressed statistically significant elevations of percent analgesia (% MPE) compared to air exposed rats. Rats exposed to 30% nitrous oxide showed no significant difference in percent analgesia. Pretreatment with naloxone (10 mg/kg s.c.) produced a significant decrease in % MPE and an increase in variance of response after exposures to 80% nitrous oxide in a double blind study. Kainic acid lesions of the ventral and caudal periaqueductal grey (PAG) reversed analgesia produced by 80% nitrous oxide in a crossover blink study compared to saline lesions. In conclusion, this evidence suggests that the caudal-PAG-raphe mangus-dorsal horn pain inhibition pathway is in part involved in the analgesia induced by nitrous oxide.

Original language	English (US)
Pages (from-to)	51-60
Number of pages	10
Journal	European Journal of Pharmacology
Volume	142
Issue number	1
DOIs	https://doi.org/10.1016/0014-2999(87)90653-4
State	Published - Oct 6 1987

Keywords

Analgesia
Kainic acid
Naloxone
Nitrous oxide
Opioids
Periaqueductal grey

ASJC Scopus subject areas

Pharmacology

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10.1016/0014-2999(87)90653-4

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title = "Nitrous oxide analgesia: partial antagonism by naloxone and total reversal after periaqueductal gray lesions in the rat",

abstract = "Analgesia induced by nitrous oxide was examined using radiant heat tail flick and electrical evoked foot flick tests in rats. Rats exposed to 80 and 60% nitrous oxide expressed statistically significant elevations of percent analgesia (% MPE) compared to air exposed rats. Rats exposed to 30% nitrous oxide showed no significant difference in percent analgesia. Pretreatment with naloxone (10 mg/kg s.c.) produced a significant decrease in % MPE and an increase in variance of response after exposures to 80% nitrous oxide in a double blind study. Kainic acid lesions of the ventral and caudal periaqueductal grey (PAG) reversed analgesia produced by 80% nitrous oxide in a crossover blink study compared to saline lesions. In conclusion, this evidence suggests that the caudal-PAG-raphe mangus-dorsal horn pain inhibition pathway is in part involved in the analgesia induced by nitrous oxide.",

keywords = "Analgesia, Kainic acid, Naloxone, Nitrous oxide, Opioids, Periaqueductal grey",

author = "Zuniga, {John R} and Shirley Joseph and Karl Knigge",

note = "Funding Information: The authors would like to acknowledge Mrs. Terry Gefell for her excellent technical assistance and Ms. Loft Beal for preparation of the manuscript. This research was supported in part by the Eastman Dental Center Foundation Teacher Training Grant and NRSA Grant NS07184A-05.",

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doi = "10.1016/0014-2999(87)90653-4",

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AU - Joseph, Shirley

AU - Knigge, Karl

N1 - Funding Information: The authors would like to acknowledge Mrs. Terry Gefell for her excellent technical assistance and Ms. Loft Beal for preparation of the manuscript. This research was supported in part by the Eastman Dental Center Foundation Teacher Training Grant and NRSA Grant NS07184A-05.

PY - 1987/10/6

Y1 - 1987/10/6

N2 - Analgesia induced by nitrous oxide was examined using radiant heat tail flick and electrical evoked foot flick tests in rats. Rats exposed to 80 and 60% nitrous oxide expressed statistically significant elevations of percent analgesia (% MPE) compared to air exposed rats. Rats exposed to 30% nitrous oxide showed no significant difference in percent analgesia. Pretreatment with naloxone (10 mg/kg s.c.) produced a significant decrease in % MPE and an increase in variance of response after exposures to 80% nitrous oxide in a double blind study. Kainic acid lesions of the ventral and caudal periaqueductal grey (PAG) reversed analgesia produced by 80% nitrous oxide in a crossover blink study compared to saline lesions. In conclusion, this evidence suggests that the caudal-PAG-raphe mangus-dorsal horn pain inhibition pathway is in part involved in the analgesia induced by nitrous oxide.

AB - Analgesia induced by nitrous oxide was examined using radiant heat tail flick and electrical evoked foot flick tests in rats. Rats exposed to 80 and 60% nitrous oxide expressed statistically significant elevations of percent analgesia (% MPE) compared to air exposed rats. Rats exposed to 30% nitrous oxide showed no significant difference in percent analgesia. Pretreatment with naloxone (10 mg/kg s.c.) produced a significant decrease in % MPE and an increase in variance of response after exposures to 80% nitrous oxide in a double blind study. Kainic acid lesions of the ventral and caudal periaqueductal grey (PAG) reversed analgesia produced by 80% nitrous oxide in a crossover blink study compared to saline lesions. In conclusion, this evidence suggests that the caudal-PAG-raphe mangus-dorsal horn pain inhibition pathway is in part involved in the analgesia induced by nitrous oxide.

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KW - Kainic acid

KW - Naloxone

KW - Nitrous oxide

KW - Opioids

KW - Periaqueductal grey

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Nitrous oxide analgesia: partial antagonism by naloxone and total reversal after periaqueductal gray lesions in the rat

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