NICOTINIC ACETYLCHOLINE RECEPTOR OF MAMMALIAN BRAIN: NAJA TOXIN BINDING TO SUBCELLULAR FRACTIONS OF RAT BRAIN

R. S A Tindall; M. Kent; F. Baskin; R. N. Rosenberg

doi:10.1111/j.1471-4159.1978.tb10794.x

NICOTINIC ACETYLCHOLINE RECEPTOR OF MAMMALIAN BRAIN: NAJA TOXIN BINDING TO SUBCELLULAR FRACTIONS OF RAT BRAIN

R. S A Tindall, M. Kent, F. Baskin, R. N. Rosenberg

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Abstract— Subcellular fractions of rat brain cortex bound 6.8 ± 0.4 fmol of ¹²⁵I‐labeled α‐naja toxin per milligram of protein. Toxin binding was saturable and specific e.g. nicotinic agonist and antagonist blockable. Regions in rat brain varied in saturable, specific toxin binding with hippocampus, olfactory area and corpus striatum displaying greatest toxin binding. We conclude that ¹²⁵I‐α‐naja toxin is a suitable probe for nicotinic cholinergic receptor in brain.

Original language	English (US)
Pages (from-to)	859-863
Number of pages	5
Journal	Journal of Neurochemistry
Volume	30
Issue number	4
DOIs	https://doi.org/10.1111/j.1471-4159.1978.tb10794.x
State	Published - Apr 1978

ASJC Scopus subject areas

Biochemistry
Cellular and Molecular Neuroscience

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title = "NICOTINIC ACETYLCHOLINE RECEPTOR OF MAMMALIAN BRAIN: NAJA TOXIN BINDING TO SUBCELLULAR FRACTIONS OF RAT BRAIN",

abstract = "Abstract— Subcellular fractions of rat brain cortex bound 6.8 ± 0.4 fmol of 125I‐labeled α‐naja toxin per milligram of protein. Toxin binding was saturable and specific e.g. nicotinic agonist and antagonist blockable. Regions in rat brain varied in saturable, specific toxin binding with hippocampus, olfactory area and corpus striatum displaying greatest toxin binding. We conclude that 125I‐α‐naja toxin is a suitable probe for nicotinic cholinergic receptor in brain.",

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AU - Rosenberg, R. N.

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AB - Abstract— Subcellular fractions of rat brain cortex bound 6.8 ± 0.4 fmol of 125I‐labeled α‐naja toxin per milligram of protein. Toxin binding was saturable and specific e.g. nicotinic agonist and antagonist blockable. Regions in rat brain varied in saturable, specific toxin binding with hippocampus, olfactory area and corpus striatum displaying greatest toxin binding. We conclude that 125I‐α‐naja toxin is a suitable probe for nicotinic cholinergic receptor in brain.

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NICOTINIC ACETYLCHOLINE RECEPTOR OF MAMMALIAN BRAIN: NAJA TOXIN BINDING TO SUBCELLULAR FRACTIONS OF RAT BRAIN

Abstract

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