TY - JOUR
T1 - Nicardipine and propranolol in the treatment of hypertension
T2 - Similar antihypertensive but dissimilar hemodynamic actions
AU - Venkata, C.
AU - Ram, S.
AU - Gonzalez, Domingo G.
AU - Featherston, William
AU - Lugo, Carlos
AU - Ralakis, Joanie
AU - Kaplan, Norman M
PY - 1990/2
Y1 - 1990/2
N2 - Although the precise cause of essential hypertension is not known, empiric treatment is indicated to reduce cardiovascular risks. Several pharmacologic classes of antihypertensive drugs are available to reduce blood pressure, but they do so by different hemodynamic mechanisms. The physiologic therapeutic goal in patients with hypertension is to normalize the systemic vascular resistance without inducing major alterations in the cardiac output. In this study we compared the antihypertensive and hemodynamic actions of nicardipine, a calcium antagonist, with propranolol, a β-blocking drug. Both drugs were effective in the treatment of hypertension. However, while propranolol therapy decreased the resting and exercise left ventricular ejection fraction and cardiac output, cardiac function was well preserved during nicardipine therapy. It is concluded that both nicardipine and propranolol exert similar antihypertensive actions but that they cause dissimilar hemodynamic consequences in patients with uncomplicated hypertension.
AB - Although the precise cause of essential hypertension is not known, empiric treatment is indicated to reduce cardiovascular risks. Several pharmacologic classes of antihypertensive drugs are available to reduce blood pressure, but they do so by different hemodynamic mechanisms. The physiologic therapeutic goal in patients with hypertension is to normalize the systemic vascular resistance without inducing major alterations in the cardiac output. In this study we compared the antihypertensive and hemodynamic actions of nicardipine, a calcium antagonist, with propranolol, a β-blocking drug. Both drugs were effective in the treatment of hypertension. However, while propranolol therapy decreased the resting and exercise left ventricular ejection fraction and cardiac output, cardiac function was well preserved during nicardipine therapy. It is concluded that both nicardipine and propranolol exert similar antihypertensive actions but that they cause dissimilar hemodynamic consequences in patients with uncomplicated hypertension.
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U2 - 10.1016/S0002-8703(05)80070-5
DO - 10.1016/S0002-8703(05)80070-5
M3 - Article
C2 - 2301245
AN - SCOPUS:0025021067
SN - 0002-8703
VL - 119
SP - 463
EP - 467
JO - American heart journal
JF - American heart journal
IS - 2 PART 2
ER -