NFAT signaling: Choreographing the social lives of cells

Gerald R. Crabtree; Eric N. Olson

doi:10.1016/S0092-8674(02)00699-2

NFAT signaling: Choreographing the social lives of cells

Gerald R. Crabtree, Eric N. Olson

Research output: Contribution to journal › Review article › peer-review

1132 Scopus citations

Abstract

Calcium signaling activates the phosphatase calcineurin and induces movement of NFATc proteins into the nucleus, where they cooperate with other proteins to form complexes on DNA. Nuclear import is opposed by kinases such as GSK3, thereby rendering transcription continuously responsive to receptor occupancy. Disruptions of the genes involved in NFAT signaling are implicating this pathway as a regulator of developmental cell-cell interactions.

Original language	English (US)
Pages (from-to)	S67-S79
Journal	Cell
Volume	109
Issue number	2 SUPPL. 1
DOIs	https://doi.org/10.1016/S0092-8674(02)00699-2
State	Published - 2002

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/S0092-8674(02)00699-2

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title = "NFAT signaling: Choreographing the social lives of cells",

abstract = "Calcium signaling activates the phosphatase calcineurin and induces movement of NFATc proteins into the nucleus, where they cooperate with other proteins to form complexes on DNA. Nuclear import is opposed by kinases such as GSK3, thereby rendering transcription continuously responsive to receptor occupancy. Disruptions of the genes involved in NFAT signaling are implicating this pathway as a regulator of developmental cell-cell interactions.",

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AB - Calcium signaling activates the phosphatase calcineurin and induces movement of NFATc proteins into the nucleus, where they cooperate with other proteins to form complexes on DNA. Nuclear import is opposed by kinases such as GSK3, thereby rendering transcription continuously responsive to receptor occupancy. Disruptions of the genes involved in NFAT signaling are implicating this pathway as a regulator of developmental cell-cell interactions.

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NFAT signaling: Choreographing the social lives of cells

Abstract

ASJC Scopus subject areas

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