@article{7567eb6b976c49699d6487a3dcf22396,
title = "New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries",
abstract = "Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of European ancestry, we define 279 lung function signals, 139 of which are new. In combination, these variants strongly predict COPD in independent populations. Furthermore, the combined effect of these variants showed generalizability across smokers and never smokers, and across ancestral groups. We highlight biological pathways, known and potential drug targets for COPD and, in phenome-wide association studies, autoimmune-related and other pleiotropic effects of lung function–associated variants. This new genetic evidence has potential to improve future preventive and therapeutic strategies for COPD.",
author = "{Understanding Society Scientific Group} and Nick Shrine and Guyatt, {Anna L.} and Erzurumluoglu, {A. Mesut} and Jackson, {Victoria E.} and Hobbs, {Brian D.} and Melbourne, {Carl A.} and Chiara Batini and Fawcett, {Katherine A.} and Kijoung Song and Phuwanat Sakornsakolpat and Xingnan Li and Ruth Boxall and Reeve, {Nicola F.} and Ma{\textquoteright}en Obeidat and Zhao, {Jing Hua} and Matthias Wielscher and Stefan Weiss and Kentistou, {Katherine A.} and Cook, {James P.} and Sun, {Benjamin B.} and Jian Zhou and Jennie Hui and Stefan Karrasch and Medea Imboden and Harris, {Sarah E.} and Jonathan Marten and Stefan Enroth and Kerr, {Shona M.} and Ida Surakka and Veronique Vitart and Terho Lehtim{\"a}ki and Allen, {Richard J.} and Bakke, {Per S.} and Beaty, {Terri H.} and Bleecker, {Eugene R.} and Yohan Boss{\'e} and Brandsma, {Corry Anke} and Zhengming Chen and Crapo, {James D.} and John Danesh and DeMeo, {Dawn L.} and Frank Dudbridge and Ralf Ewert and Christian Gieger and Amund Gulsvik and Hansell, {Anna L.} and Ke Hao and Hoffman, {Joshua D.} and Hokanson, {John E.} and Georg Homuth",
note = "Funding Information: This research has been conducted using the UK Biobank Resource under applications 648, 4892 and 26041. L. Wain holds a GSK/British Lung Foundation Chair in Respiratory Research. M. Tobin is supported by a Wellcome Trust Investigator Award (WT202849/ Z/16/Z). M. Tobin and L. Wain have been supported by the Medical Research Council (MRC) (MR/N011317/1). The research was partially supported by the National Institute for Health Research (NIHR) Leicester Biomedical Research Centre; the views expressed are those of the author(s) and not necessarily those of the National Health Service (NHS), the NIHR or the Department of Health. I.H. was partially supported by the NIHR Nottingham Biomedical Research Centre; the views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health. This research used the ALICE and SPECTRE High Performance Computing Facilities at the University of Leicester. Additional acknowledgments and funding details for other co-authors and contributing studies (including the SpiroMeta consortium) are in the Supplementary Note. Publisher Copyright: {\textcopyright} 2019, The Author(s), under exclusive licence to Springer Nature America, Inc.",
year = "2019",
month = mar,
day = "1",
doi = "10.1038/s41588-018-0321-7",
language = "English (US)",
volume = "51",
pages = "481--493",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "3",
}