New functions for an ancient domain

W. Lee Kraus

doi:10.1038/nsmb0909-904

New functions for an ancient domain

W. Lee Kraus

Research output: Contribution to journal › Short survey › peer-review

32 Scopus citations

Abstract

Macrodomains function as binding modules for metabolites of NAD ⁺, including poly(ADP-ribose). Three new studies explore how binding of poly(ADP-ribose) by the macrodomains of histone variant macroH2A1.1 and the ATP-dependent chromatin-remodeling protein ALC1 (also called CHD1L) leads to the modulation of chromatin structure, regulating nuclear functions such as DNA-damage detection and repair.

Original language	English (US)
Pages (from-to)	904-907
Number of pages	4
Journal	Nature Structural and Molecular Biology
Volume	16
Issue number	9
DOIs	https://doi.org/10.1038/nsmb0909-904
State	Published - Sep 2009

ASJC Scopus subject areas

Structural Biology
Molecular Biology

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abstract = "Macrodomains function as binding modules for metabolites of NAD +, including poly(ADP-ribose). Three new studies explore how binding of poly(ADP-ribose) by the macrodomains of histone variant macroH2A1.1 and the ATP-dependent chromatin-remodeling protein ALC1 (also called CHD1L) leads to the modulation of chromatin structure, regulating nuclear functions such as DNA-damage detection and repair.",

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AB - Macrodomains function as binding modules for metabolites of NAD +, including poly(ADP-ribose). Three new studies explore how binding of poly(ADP-ribose) by the macrodomains of histone variant macroH2A1.1 and the ATP-dependent chromatin-remodeling protein ALC1 (also called CHD1L) leads to the modulation of chromatin structure, regulating nuclear functions such as DNA-damage detection and repair.

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New functions for an ancient domain

Abstract

ASJC Scopus subject areas

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