TY - JOUR
T1 - New discoveries in the pathogenesis and classification of vitiligo
AU - Vitiligo Working Group
AU - Rodrigues, Michelle
AU - Ezzedine, Khaled
AU - Hamzavi, Iltefat
AU - Pandya, Amit G.
AU - Harris, John E.
N1 - Publisher Copyright:
© 2016 American Academy of Dermatology, Inc.
PY - 2017/7
Y1 - 2017/7
N2 - Vitiligo is a common autoimmune disease that progressively destroys melanocytes in the skin, resulting in the appearance of patchy depigmentation. This disfiguring condition frequently affects the face and other visible areas of the body, which can be psychologically devastating. The onset of vitiligo often occurs in younger individuals and progresses for life, resulting in a heavy burden of disease and decreased quality of life. Presentation patterns of vitiligo vary, and recognition of these patterns provides both diagnostic and prognostic clues. Recent insights into disease pathogenesis offer a better understanding of the natural history of the disease, its associations, and potential for future treatments. The first article in this continuing medical education series outlines typical and atypical presentations of vitiligo, how they reflect disease activity, prognosis, and response to treatment. Finally, we discuss disease associations, risk factors, and our current understanding of disease pathogenesis.
AB - Vitiligo is a common autoimmune disease that progressively destroys melanocytes in the skin, resulting in the appearance of patchy depigmentation. This disfiguring condition frequently affects the face and other visible areas of the body, which can be psychologically devastating. The onset of vitiligo often occurs in younger individuals and progresses for life, resulting in a heavy burden of disease and decreased quality of life. Presentation patterns of vitiligo vary, and recognition of these patterns provides both diagnostic and prognostic clues. Recent insights into disease pathogenesis offer a better understanding of the natural history of the disease, its associations, and potential for future treatments. The first article in this continuing medical education series outlines typical and atypical presentations of vitiligo, how they reflect disease activity, prognosis, and response to treatment. Finally, we discuss disease associations, risk factors, and our current understanding of disease pathogenesis.
KW - chemical leukoderma
KW - confetti depigmentation
KW - halo nevi
KW - leukoderma
KW - segmental vitiligo
KW - vitiligo
KW - vitiligo pathogenesis
UR - http://www.scopus.com/inward/record.url?scp=85020877149&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85020877149&partnerID=8YFLogxK
U2 - 10.1016/j.jaad.2016.10.048
DO - 10.1016/j.jaad.2016.10.048
M3 - Review article
C2 - 28619550
AN - SCOPUS:85020877149
SN - 0190-9622
VL - 77
SP - 1
EP - 13
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 1
ER -