Abstract
Objective: Systemic inflammation may be a common mechanism for the development of osteoporosis (OP) and atherosclerosis. Elevated arterial stiffness is an index of subclinical atherosclerosis. Recent studies found that neutrophil/lymphocyte ratio (NLR), is a useful marker of cardiovascular disease and a more powerful predictor than any other leukocyte subtypes. However, little research has been conducted to investigate the relationship between NLR and arterial stiffness measured by brachial-ankle pulse wave velocity (baPWV). Methods: In this cross-sectional study, we examined the relationship between NLR and baPWV in 512 subjects. Results: Compared to the control subjects, NLR and baPWV increased in patients with OP. Partial correlation analysis revealed that there was a significant correlation between NLR and baPWV after adjusting for confounding factors in OP. Multivariate linear regression analysis showed that NLR was a significant factor for increased baPWV in patients with OP (. β=. 0.249, p<. 0.001). However, there was no association between NLR and baPWV in control subjects. Conclusion: NLR and baPWV are elevated in OP. Moreover, NLR is independently associated with baPWV. Further studies are warranted to investigate whether anti-inflammatory treatment could improve arterial stiffness in postmenopausal women with OP.
Original language | English (US) |
---|---|
Pages (from-to) | 76-80 |
Number of pages | 5 |
Journal | Archives of Gerontology and Geriatrics |
Volume | 61 |
Issue number | 1 |
DOIs | |
State | Published - Jul 1 2015 |
Keywords
- Arterial stiffness
- Brachial-ankle pulse wave velocity
- Inflammation
- Neutrophil-lymphocyte ratio
- Osteoporosis
ASJC Scopus subject areas
- Health(social science)
- Aging
- Gerontology
- Geriatrics and Gerontology