TY - JOUR
T1 - Neuropsychological function in young children who have undergone liver transplantation
AU - Stewart, Sunita M.
AU - Silver, Cheryl H.
AU - Nici, Janice
AU - Waller, David
AU - Campbell, Richard
AU - Uauy, Ricardo
AU - Andrews, Walter S.
N1 - Funding Information:
1Preparation of this article was supported in part by the Clinical Research Center, Pediatric Subunit, U.S. Public Health Service Grant MO1-RR0G63. We gratefully acknowledge the assistance of Betsy Fyock and Jill Knussman in subject recruitment, and Margareta Benser and Alice Cunningham in anthropometric data collection. 2A11 correspondence should be sent to Sunita M. Stewart, Psychiatry Department, Children's Medical Center, 1935 Motor Street, Dallas, Texas 75235.
PY - 1991/10
Y1 - 1991/10
N2 - Presented neuropsychological data from 20 patients between the ages of 4 and 9 years, who had undergone liver transplantation at least 12 months prior to study participation, and compared them to a control group of 20 children with cystic fibrosis. The liver transplant group showed deficits in VIQ, PIQ, visual-spatial and abstraction/reasoning skills, but not in alertness/concentration, motor, or sensory-perceptual functions. On motor and sensory-perceptual tests, no differences were found in direction of lateralization of deficits. Visual-spatial deficits found in this study sample are similar to those found in adults with end-stage liver disease and in a previous report of an overall older group of children following liver transplantation. However younger children have greater evidence of generalized impairment and VIQ deficits which have not been found in older groups. Findings are discussed in relation to possible etiology, location of brain damage, and clinical implications.
AB - Presented neuropsychological data from 20 patients between the ages of 4 and 9 years, who had undergone liver transplantation at least 12 months prior to study participation, and compared them to a control group of 20 children with cystic fibrosis. The liver transplant group showed deficits in VIQ, PIQ, visual-spatial and abstraction/reasoning skills, but not in alertness/concentration, motor, or sensory-perceptual functions. On motor and sensory-perceptual tests, no differences were found in direction of lateralization of deficits. Visual-spatial deficits found in this study sample are similar to those found in adults with end-stage liver disease and in a previous report of an overall older group of children following liver transplantation. However younger children have greater evidence of generalized impairment and VIQ deficits which have not been found in older groups. Findings are discussed in relation to possible etiology, location of brain damage, and clinical implications.
KW - CNS
KW - Children
KW - Liver transplantation
KW - Neuropsychological assessment
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U2 - 10.1093/jpepsy/16.5.569
DO - 10.1093/jpepsy/16.5.569
M3 - Article
C2 - 1744806
AN - SCOPUS:0026042649
SN - 0146-8693
VL - 16
SP - 569
EP - 583
JO - Journal of pediatric psychology
JF - Journal of pediatric psychology
IS - 5
ER -