@article{b6eeaf50ce1044c69ec26408e3e21cbf,
title = "Neuroprotection for hypoxic-ischemic encephalopathy: Contributions from the neonatal research network",
abstract = "Therapeutic hypothermia (TH) is now well established as the standard of care treatment for moderate to severe neonatal encephalopathy secondary to perinatal hypoxic ischemic encephalopathy (HIE) in infants ≥36 weeks gestation in high income countries. The Neonatal Research Network (NRN) contributed greatly to the study of TH as a neuroprotectant with three trials now completed in infants ≥36 weeks gestation and the only large randomized-controlled trial of TH in preterm infants now in the follow-up phase. Data from the first NRN TH trial combined with data from other large trials of TH affirm the safety and neuroprotective qualities of TH and highlight the importance of providing TH to all infants who qualify. In this review we will highlight the findings of the three NRN trials of TH in the term infant population and the secondary analyses that continue to inform the care of patients with HIE.",
author = "Bonifacio, {Sonia Lomeli} and Chalak, {Lina F.} and {Van Meurs}, {Krisa P.} and Laptook, {Abbot R.} and Seetha Shankaran",
note = "Funding Information: The Prediction of Outcome using aEEG secondary study received supplemental financial support from the Best Pharmaceuticals for Children Act and was performed at 16 sites participating in the OC RCT. A reliable and accurate bedside method to predict death or disability is needed to better inform decision making by physicians and parents early in the neonatal course. aEEG is a simple, non-invasive bedside technology that permits continuous evaluation of cortical cerebral electrical activity. The aEEG data are derived following a process where the raw EEG tracing is filtered, amplified, rectified, and then displayed in a time-compressed, semi-logarithmic fashion. Current aEEG devices display the compressed as well as the raw EEG tracing allowing for evaluation of the background activity of the brain, displaying changes in the background activity over time, and enabling screening for seizure activity. Publisher Copyright: {\textcopyright} 2022",
year = "2022",
doi = "10.1016/j.semperi.2022.151639",
language = "English (US)",
journal = "Seminars in Perinatology",
issn = "0146-0005",
publisher = "W.B. Saunders Ltd",
}