TY - JOUR
T1 - Neuropathy associated with hyperoxaluria
T2 - Improvement after combined renal and liver transplantations
AU - Galloway, Gloria
AU - Giuliani, Michael J.
AU - Burns, Dennis K.
AU - Lacomis, David
PY - 1998
Y1 - 1998
N2 - Little is known about oxaluria-associated neuropathy, and no effective treatments have been described. We report two patients with clinically severe and progressive sensorimotor polyneuropathy associated with oxaluria. Electrodiagnostic testing and sural nerve histopathology revealed evidence of severe axon loss and demyelination. In addition, birefringent crystalline deposits were identified within endoneurial and parineurial blood vessel walls, axon cylinders, and perimysial blood vessel walls. Electron probe microscopy confirmed that calcium (consistent with calcium oxalate) was a major constituent of the crystals. Both patients had substantial improvement in neuropathic signs and symptoms after kidney and liver transplantations despite no prior improvement with hemodialysis. Our results confirm previous reports of a mixed axonal and demyelinating neuropathy with calcium oxalate deposition in association with oxaluria. In addition, our findings suggest that renal and liver transplantation may be potential treatments for the associated neuropathy.
AB - Little is known about oxaluria-associated neuropathy, and no effective treatments have been described. We report two patients with clinically severe and progressive sensorimotor polyneuropathy associated with oxaluria. Electrodiagnostic testing and sural nerve histopathology revealed evidence of severe axon loss and demyelination. In addition, birefringent crystalline deposits were identified within endoneurial and parineurial blood vessel walls, axon cylinders, and perimysial blood vessel walls. Electron probe microscopy confirmed that calcium (consistent with calcium oxalate) was a major constituent of the crystals. Both patients had substantial improvement in neuropathic signs and symptoms after kidney and liver transplantations despite no prior improvement with hemodialysis. Our results confirm previous reports of a mixed axonal and demyelinating neuropathy with calcium oxalate deposition in association with oxaluria. In addition, our findings suggest that renal and liver transplantation may be potential treatments for the associated neuropathy.
UR - http://www.scopus.com/inward/record.url?scp=0031900515&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031900515&partnerID=8YFLogxK
U2 - 10.1111/j.1750-3639.1998.tb00150.x
DO - 10.1111/j.1750-3639.1998.tb00150.x
M3 - Article
C2 - 9546283
AN - SCOPUS:0031900515
SN - 1015-6305
VL - 8
SP - 247
EP - 251
JO - Brain Pathology
JF - Brain Pathology
IS - 2
ER -