Neurodevelopmental status and adaptive behaviors in preschool children with chronic kidney disease

Peter J. Duquette, Stephen R. Hooper, Phil F. Icard, Sarah J. Hower, Eva G. Mamak, Crista E. Wetherington, Debbie S. Gipson

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


This study examines the early neurodevelopmental function of infants and preschool children who have chronic kidney disease (CKD). Fifteen patients with CKD are compared to a healthy control group using the Mullen Scales of Early Learning (MSEL) and the Vineland Adaptive Behavior Scale (VABS). Multivariate analysis reveals significant differences between the CKD and control groups on both MSEL (p <.01) and VABS (p <.001) composite scales, with the group with CKD obtaining lower scores on both composites. A higher proportion of children with CKD meet federal eligibility criteria for early cognitive delay, but similar proportions are found across adaptive behaviors. Disease severity is positively correlated to cognitive and adaptive functioning such that lower scores are associated with less renal function (MSEL r =.62, p <.001; VABS r =.70, p <.001). Suggestions are made in regard to special education assessment and service provision.

Original languageEnglish (US)
Pages (from-to)45-51
Number of pages7
JournalJournal of Special Education
Issue number1
StatePublished - May 2009


  • Cognition
  • Infants
  • Kidney failure
  • Preschool children
  • Special education

ASJC Scopus subject areas

  • Education
  • Rehabilitation


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