Neuroanatomical substrates of depression in the elderly

K. Ranga R Krishnan, William M. McDonald, P. Murali Doraiswamy, Larry A. Tupler, Mustafa Husain, Orest B. Boyko, Gary S. Figiel, Everett H. Ellinwood

Research output: Contribution to journalArticlepeer-review

161 Scopus citations


The etiology of depression in the elderly is poorly understood. In this study, magnetic resonance imaging was used to evaluate the role of subcortical structures in the pathophysiology of depression in the elderly. Elderly depressed patients were found to have smaller caudate nuclei, smaller putaminal complexes and in increased frequency of subcortical hyperintensities compared with normal, healthy controls. These findings were more pronounced in patients with lateonset depression. Based on these findings, the authors discuss the role of the basal ganglia in the pathophysiology of depression in the elderly.

Original languageEnglish (US)
Pages (from-to)41-46
Number of pages6
JournalEuropean Archives of Psychiatry and Clinical Neuroscience
Issue number1
StatePublished - Jul 1993


  • Basal ganglia
  • Depression
  • Magnetic resonance imaging
  • Subcortical hyperintensities

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Pharmacology (medical)


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