TY - JOUR
T1 - Neural correlates of response inhibition in pediatric bipolar disorder and attention deficit hyperactivity disorder
AU - Passarotti, Alessandra M.
AU - Sweeney, John A.
AU - Pavuluri, Mani N.
N1 - Funding Information:
Disclosure: Dr Passarotti has no financial relationships to disclose. Dr. Pavuluri's work unrelated to this manuscript is supported by NARSAD, NICHD, Colbeth Foundation, GlaxoSmithKline— NeuroHealth, Abbott Pharmaceuticals and Janssen Research Foundation. Dr. Sweeney, also unrelated to this work, has received support from NIH, GlaxoSmithKline, AstraZeneca, Janssen and Eli Lilly.
Funding Information:
This work is supported by NIH K23 RR18638-01, the Dana Foundation and NARSAD to Dr Pavuluri.
PY - 2010/1/30
Y1 - 2010/1/30
N2 - Impulsivity, inattention and poor behavioral inhibition are common deficits in pediatric bipolar disorder (PBD) and attention deficit hyperactivity disorder (ADHD). This study aimed to identify similarities and differences in the neural substrate of response inhibition deficits that are associated with these disorders. A functional magnetic resonance imaging (fMRI) study was conducted on 15 unmedicated PBD patients (Type I, manic/mixed), 11 unmedicated ADHD patients, and 15 healthy controls (HC) (mean age = 13.5 years; S.D. = 3.5). A response inhibition task examined the ability to inhibit a motor response to a target when a stop cue appeared shortly after. The PBD and ADHD groups did not differ on behavioral performance, although both groups were less accurate than the HC group. fMRI findings showed that for trials requiring response inhibition, the ADHD group, relative to the PBD and HC groups, demonstrated reduced activation in both ventrolateral (VLPFC) and dorsolateral (DLPFC) prefrontal cortex, and increased bilateral caudate activation compared with HC. The PBD group, relative to HC, showed decreased activation in the left VLPFC, at the junction of the inferior and middle frontal gyri, and in the right anterior cingulate cortex (ACC). Prefrontal dysfunction was observed in both the ADHD and PBD groups relative to HC, although it was more extensive and accompanied by subcortical overactivity in ADHD.
AB - Impulsivity, inattention and poor behavioral inhibition are common deficits in pediatric bipolar disorder (PBD) and attention deficit hyperactivity disorder (ADHD). This study aimed to identify similarities and differences in the neural substrate of response inhibition deficits that are associated with these disorders. A functional magnetic resonance imaging (fMRI) study was conducted on 15 unmedicated PBD patients (Type I, manic/mixed), 11 unmedicated ADHD patients, and 15 healthy controls (HC) (mean age = 13.5 years; S.D. = 3.5). A response inhibition task examined the ability to inhibit a motor response to a target when a stop cue appeared shortly after. The PBD and ADHD groups did not differ on behavioral performance, although both groups were less accurate than the HC group. fMRI findings showed that for trials requiring response inhibition, the ADHD group, relative to the PBD and HC groups, demonstrated reduced activation in both ventrolateral (VLPFC) and dorsolateral (DLPFC) prefrontal cortex, and increased bilateral caudate activation compared with HC. The PBD group, relative to HC, showed decreased activation in the left VLPFC, at the junction of the inferior and middle frontal gyri, and in the right anterior cingulate cortex (ACC). Prefrontal dysfunction was observed in both the ADHD and PBD groups relative to HC, although it was more extensive and accompanied by subcortical overactivity in ADHD.
KW - Attention
KW - Bipolar
KW - Child
KW - Development
KW - Functional magnetic resonance imaging (fMRI)
UR - http://www.scopus.com/inward/record.url?scp=71849100430&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=71849100430&partnerID=8YFLogxK
U2 - 10.1016/j.pscychresns.2009.07.002
DO - 10.1016/j.pscychresns.2009.07.002
M3 - Article
C2 - 19926457
AN - SCOPUS:71849100430
SN - 0925-4927
VL - 181
SP - 36
EP - 43
JO - Psychiatry Research - Neuroimaging
JF - Psychiatry Research - Neuroimaging
IS - 1
ER -