TY - JOUR
T1 - Neonatal outcomes in twin pregnancies delivered moderately preterm, late preterm, and term
AU - Refuerzo, Jerrie S.
AU - Momirova, Valerija
AU - Peaceman, Alan M.
AU - Sciscione, Anthony
AU - Rouse, Dwight J.
AU - Caritis, Steve N.
AU - Spong, Catherine Y.
AU - Varner, Michael W.
AU - Malone, Fergal D.
AU - Iams, Jay D.
AU - Mercer, Brian M.
AU - Thorp, John M.
AU - Sorokin, Yoram
AU - Carpenter, Marshall W.
AU - Lo, Julie
AU - Harper, Margaret
PY - 2010
Y1 - 2010
N2 - We compared neonatal outcomes in twin pregnancies following moderately preterm birth (MPTB), late preterm birth (LPTB), and term birth. A secondary analysis of a multicenter, randomized controlled trial of multiple gestations was conducted. MPTB was defined as delivery between 320/7 and 33 6/7 weeks and LPTB between 340/7 and 366/7 weeks. Primary outcome was a neonatal outcome composite consisting of one or more of the following: Neonatal death, respiratory distress syndrome, early onset culture-proven sepsis, stage 2 or 3 necrotizing enterocolitis, bronchopulmonary dysplasia, grade 3 or 4 intraventricular hemorrhage, periventricular leukomalacia, pneumonia, or severe retinopathy of prematurity. Among 552 twin pregnancies, the MPTB rate was 14.5%, LPTB 49.8%, and term birth rate 35.7%. The rate of the primary outcome was different between groups: 30.0% for MPTB, 12.8% for LPTB, 0.5% for term birth (p<0.001). Compared with term neonates, the primary neonatal outcome composite was increased following MPTB (relative risk [RR] 58.5; 95% confidence interval [CI] 11.3 to 1693.0) and LPTB (RR 24.9; 95% CI 4.8 to 732.2). Twin pregnancies born moderately and late preterm encounter higher rates of neonatal morbidities compared with twins born at term.
AB - We compared neonatal outcomes in twin pregnancies following moderately preterm birth (MPTB), late preterm birth (LPTB), and term birth. A secondary analysis of a multicenter, randomized controlled trial of multiple gestations was conducted. MPTB was defined as delivery between 320/7 and 33 6/7 weeks and LPTB between 340/7 and 366/7 weeks. Primary outcome was a neonatal outcome composite consisting of one or more of the following: Neonatal death, respiratory distress syndrome, early onset culture-proven sepsis, stage 2 or 3 necrotizing enterocolitis, bronchopulmonary dysplasia, grade 3 or 4 intraventricular hemorrhage, periventricular leukomalacia, pneumonia, or severe retinopathy of prematurity. Among 552 twin pregnancies, the MPTB rate was 14.5%, LPTB 49.8%, and term birth rate 35.7%. The rate of the primary outcome was different between groups: 30.0% for MPTB, 12.8% for LPTB, 0.5% for term birth (p<0.001). Compared with term neonates, the primary neonatal outcome composite was increased following MPTB (relative risk [RR] 58.5; 95% confidence interval [CI] 11.3 to 1693.0) and LPTB (RR 24.9; 95% CI 4.8 to 732.2). Twin pregnancies born moderately and late preterm encounter higher rates of neonatal morbidities compared with twins born at term.
KW - Twin pregnancy
KW - late preterm birth
KW - neonatal morbidities
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U2 - 10.1055/s-0030-1248940
DO - 10.1055/s-0030-1248940
M3 - Article
C2 - 20175042
AN - SCOPUS:77954882763
SN - 0735-1631
VL - 27
SP - 537
EP - 542
JO - American Journal of Perinatology
JF - American Journal of Perinatology
IS - 7
ER -