Near infrared photonic finger imager for prostate cancer screening

Y. Pu, W. B. Wang, M. Xu, G. C. Tang, Y. Budansky, M. Sharanov, S. Achilefu, J. A. Eastham, R. R. Alfano

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


A portable rectal near infrared (NIR) scanning polarization imaging unit with an optical fiber-based rectal probe, designated as a Photonic Finger (PF), was designed, developed, built and tested. PF was used to image and locate the three dimensional (3D) positions of abnormal prostate tissue embedded inside normal prostate tissue. An inverse image reconstruction algorithm, namely Optical Tomography using Independent Component Analysis (OPTICA) was developed to unmix the signal from targets (cancerous tissue) embedded in a turbid media (normal tissue) in the backscattering imaging geometry. The Photonic Finger combined with OPTICA was ex vivo tested to characterize different target(s) inside different tissue medium, including cancerous prostate tissue embedded inside large pieces of normal tissue. This new developed instrument, Photonic Finger, may provide an alternative imaging technique, which is accurate, of high spatial resolution and non-or-less invasive for prostate cancers screening.

Original languageEnglish (US)
Pages (from-to)507-517
Number of pages11
JournalTechnology in Cancer Research and Treatment
Issue number6
StatePublished - Dec 2011
Externally publishedYes


  • Backscattering
  • Human prostate tissue
  • Independent component analysis (ICA)
  • Optical fiber-based rectal probe
  • Photon propagation model
  • Photonic finger (PF)
  • Receptor-target contrast agents
  • Scanning optical polarization imaging
  • Three-dimensional localization

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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