Near-infrared emitting radioactive gold nanoparticles with molecular pharmacokinetics

Chen Zhou; Guiyang Hao; Patrick Thomas; Jinbin Liu; Mengxiao Yu; Shasha Sun; Orhan K. Öz; Xiankai Sun; Jie Zheng

doi:10.1002/anie.201203031

Near-infrared emitting radioactive gold nanoparticles with molecular pharmacokinetics

Chen Zhou, Guiyang Hao, Patrick Thomas, Jinbin Liu, Mengxiao Yu, Shasha Sun, Orhan K. Öz, Xiankai Sun, Jie Zheng

Research output: Contribution to journal › Article › peer-review

173 Scopus citations

Abstract

A molecular nanoprobe: Glutathione-coated near-infrared-emitting radioactive gold nanoparticles have been synthezised and behave like small-molecule contrast agents in pharmocokinetics. These nanoparticles show a rapid distribution half-life, a desirable elimination half-life, and hold promise for single-photon emission computed tomography (SPECT) and fluorescence imaging (see picture).

Original language	English (US)
Pages (from-to)	10118-10122
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	40
DOIs	https://doi.org/10.1002/anie.201203031
State	Published - Oct 1 2012

Keywords

gold
imaging agents
luminescence
nanoparticles
pharmacokinetics

ASJC Scopus subject areas

Catalysis
General Chemistry

Access to Document

10.1002/anie.201203031

Cite this

@article{9a4b93ae90d44f4681c61f0a79cec87a,

title = "Near-infrared emitting radioactive gold nanoparticles with molecular pharmacokinetics",

abstract = "A molecular nanoprobe: Glutathione-coated near-infrared-emitting radioactive gold nanoparticles have been synthezised and behave like small-molecule contrast agents in pharmocokinetics. These nanoparticles show a rapid distribution half-life, a desirable elimination half-life, and hold promise for single-photon emission computed tomography (SPECT) and fluorescence imaging (see picture).",

keywords = "gold, imaging agents, luminescence, nanoparticles, pharmacokinetics",

author = "Chen Zhou and Guiyang Hao and Patrick Thomas and Jinbin Liu and Mengxiao Yu and Shasha Sun and {\"O}z, {Orhan K.} and Xiankai Sun and Jie Zheng",

year = "2012",

month = oct,

day = "1",

doi = "10.1002/anie.201203031",

language = "English (US)",

volume = "51",

pages = "10118--10122",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "40",

}

TY - JOUR

T1 - Near-infrared emitting radioactive gold nanoparticles with molecular pharmacokinetics

AU - Zhou, Chen

AU - Hao, Guiyang

AU - Thomas, Patrick

AU - Liu, Jinbin

AU - Yu, Mengxiao

AU - Sun, Shasha

AU - Öz, Orhan K.

AU - Sun, Xiankai

AU - Zheng, Jie

PY - 2012/10/1

Y1 - 2012/10/1

N2 - A molecular nanoprobe: Glutathione-coated near-infrared-emitting radioactive gold nanoparticles have been synthezised and behave like small-molecule contrast agents in pharmocokinetics. These nanoparticles show a rapid distribution half-life, a desirable elimination half-life, and hold promise for single-photon emission computed tomography (SPECT) and fluorescence imaging (see picture).

AB - A molecular nanoprobe: Glutathione-coated near-infrared-emitting radioactive gold nanoparticles have been synthezised and behave like small-molecule contrast agents in pharmocokinetics. These nanoparticles show a rapid distribution half-life, a desirable elimination half-life, and hold promise for single-photon emission computed tomography (SPECT) and fluorescence imaging (see picture).

KW - gold

KW - imaging agents

KW - luminescence

KW - nanoparticles

KW - pharmacokinetics

UR - http://www.scopus.com/inward/record.url?scp=84867002388&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84867002388&partnerID=8YFLogxK

U2 - 10.1002/anie.201203031

DO - 10.1002/anie.201203031

M3 - Article

C2 - 22961978

AN - SCOPUS:84867002388

SN - 1433-7851

VL - 51

SP - 10118

EP - 10122

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 40

ER -

Near-infrared emitting radioactive gold nanoparticles with molecular pharmacokinetics

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this