Nanotechnology Strategies to Advance Outcomes in Clinical Cancer Care

Christopher M. Hartshorn, Michelle S. Bradbury, Gregory M. Lanza, Andre E. Nel, Jianghong Rao, Andrew Z. Wang, Ulrich B. Wiesner, Lily Yang, Piotr Grodzinski

Research output: Contribution to journalReview articlepeer-review

181 Scopus citations


Ongoing research into the application of nanotechnology for cancer treatment and diagnosis has demonstrated its advantages within contemporary oncology as well as its intrinsic limitations. The National Cancer Institute publishes the Cancer Nanotechnology Plan every 5 years since 2005. The most recent iteration helped codify the ongoing basic and translational efforts of the field and displayed its breadth with several evolving areas. From merely a technological perspective, this field has seen tremendous growth and success. However, an incomplete understanding of human cancer biology persists relative to the application of nanoscale materials within contemporary oncology. As such, this review presents several evolving areas in cancer nanotechnology in order to identify key clinical and biological challenges that need to be addressed to improve patient outcomes. From this clinical perspective, a sampling of the nano-enabled solutions attempting to overcome barriers faced by traditional therapeutics and diagnostics in the clinical setting are discussed. Finally, a strategic outlook of the future is discussed to highlight the need for next-generation cancer nanotechnology tools designed to address critical gaps in clinical cancer care.

Original languageEnglish (US)
Pages (from-to)24-43
Number of pages20
JournalACS Nano
Issue number1
StatePublished - Jan 23 2018
Externally publishedYes


  • Cancer Nanotechnology Plan
  • National Cancer Institute
  • alliance
  • biological barriers
  • cancer
  • image-guided surgery
  • immunotherapy
  • metastasis
  • nanotechnology
  • oncology
  • radiotherapy

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)


Dive into the research topics of 'Nanotechnology Strategies to Advance Outcomes in Clinical Cancer Care'. Together they form a unique fingerprint.

Cite this