Naltrexone in patients with bipolar disorder and alcohol dependence

E. Sherwood Brown; Laura Beard; Lauren Dobbs; A. John Rush

doi:10.1002/da.20213

Naltrexone in patients with bipolar disorder and alcohol dependence

E. Sherwood Brown, Laura Beard, Lauren Dobbs, A. John Rush

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Bipolar disorder is associated with very high rates of substance abuse. However, few clinical trials are reported in this population. Naltrexone is effective for alcohol dependence, but its safety and efficacy are not established in patients with bipolar disorder and alcohol dependence. A 16-week, open-label, add-on pilot study of naltrexone was conducted in 34 outpatients with bipolar disorder and alcohol dependence. Assessments included the 17-item Hamilton Rating Scale for Depression (HRSD-17), Young Mania Rating Scale (YMRS), Brief Psychiatric Rating Scale (BPRS), and an alcohol craving scale. Alcohol use was quantified. Significant improvement was observed in the HRSD-17 and YMRS, and days of alcohol use and craving decreased significantly. Naltrexone was well tolerated. Controlled trials are warranted.

Original language	English (US)
Pages (from-to)	492-495
Number of pages	4
Journal	Depression and Anxiety
Volume	23
Issue number	8
DOIs	https://doi.org/10.1002/da.20213
State	Published - Dec 20 2006

Keywords

Depression
Mania
Mood disorders
Opioid receptor
Substance dependence

ASJC Scopus subject areas

Clinical Psychology
Psychiatry and Mental health

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10.1002/da.20213

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AU - Beard, Laura

AU - Dobbs, Lauren

AU - Rush, A. John

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Naltrexone in patients with bipolar disorder and alcohol dependence

Abstract

Keywords

ASJC Scopus subject areas

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