Abstract
Foot shock stress selectively elevates dopamine metabolism in the medial frontal cortex but not nucleus accumbens or caudate nucleus. Pretreatment with a low dose of naloxone, an opiate antagonist, reversed the elevation in medial frontal cortex dopamine metabolism observed after foot shock. These data support the hypothesis that the stress-induced release of endogenous opioids cause an excitation of mesocortical dopamine neurons.
Original language | English (US) |
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Pages (from-to) | 437-439 |
Number of pages | 3 |
Journal | European Journal of Pharmacology |
Volume | 98 |
Issue number | 3-4 |
DOIs | |
State | Published - Mar 2 1984 |
Keywords
- Dopamine
- Frontal cortex
- Naloxone
- Opiates
- Stress
ASJC Scopus subject areas
- Pharmacology