NAD as a genotype-specific drug target

Szu Chieh Mei, Charles Brenner

Research output: Contribution to journalShort surveypeer-review

7 Scopus citations


Using high-throughput chemical and genetic screening, Matheny and colleagues (in this issue of Chemistry & Biology) identified STF-118804, an inhibitor of nicotinamide phosphoribosyltransferase, as a cell type-specific inhibitor of mixed-lineage leukemia with MLL chromosomal rearrangements. The approach was powerful, as is the potential for NAD as a specific cancer target.

Original languageEnglish (US)
Pages (from-to)1307-1308
Number of pages2
JournalChemistry and Biology
Issue number11
StatePublished - Nov 21 2013
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry


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