Myogenin is in an evolutionarily conserved linkage group on human chromosome 1q31-q41 and unlinked to other mapped muscle regulatory factor genes

E. Olson; D. Edmondson; W. E. Wright; V. K. Lin; J. L. Guenet; D. Simon-Chazottes; L. H. Thompson; R. L. Stallings; W. T. Schroeder; M. Duvic; D. Brock; D. Helin; M. J. Siciliano

doi:10.1016/0888-7543(90)90028-S

Myogenin is in an evolutionarily conserved linkage group on human chromosome 1q31-q41 and unlinked to other mapped muscle regulatory factor genes

E. Olson, D. Edmondson, W. E. Wright, V. K. Lin, J. L. Guenet, D. Simon-Chazottes, L. H. Thompson, R. L. Stallings, W. T. Schroeder, M. Duvic, D. Brock, D. Helin, M. J. Siciliano

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Abstract

Myogenin is a member of a family of muscle-specific regulatory factors which includes MyoD1, Myf-5, and Myf-6 (also called MRF4 and herculin). Extensive regions of sequence homology in genes for these three factors suggest duplication events associated with their evolution. In the present study, the chromosomal location of the myogenin gene in humans (MYOG), mice (Myog), and Chinese hamsters (MYOG) was determined using in situ hybridization to human metaphase chromosomes as well as segregation analysis among interspecific somatic cell hybrid panels and interspecific backcrossed mice. We localize the gene encoding myogenin to human chromosome 1q31-q41 within a linkage group homologous with a region on mouse chromosome 1 and Chinese hamster chromosome 5. The results verify the nonlinkage of MYOG to MYOD1, MYF5, and MYF6 genes and indicate that events associated with the duplication of MYOG with respect to MYOD1, MYF5, or MYF6 loci were not chromosome-wide.

Original language	English (US)
Pages (from-to)	427-434
Number of pages	8
Journal	Genomics
Volume	8
Issue number	3
DOIs	https://doi.org/10.1016/0888-7543(90)90028-S
State	Published - Nov 1990

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Genetics

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Olson, E., Edmondson, D., Wright, W. E., Lin, V. K., Guenet, J. L., Simon-Chazottes, D., Thompson, L. H., Stallings, R. L., Schroeder, W. T., Duvic, M., Brock, D., Helin, D., & Siciliano, M. J. (1990). Myogenin is in an evolutionarily conserved linkage group on human chromosome 1q31-q41 and unlinked to other mapped muscle regulatory factor genes. Genomics, 8(3), 427-434. https://doi.org/10.1016/0888-7543(90)90028-S

Olson, E, Edmondson, D, Wright, WE, Lin, VK, Guenet, JL, Simon-Chazottes, D, Thompson, LH, Stallings, RL, Schroeder, WT, Duvic, M, Brock, D, Helin, D & Siciliano, MJ 1990, 'Myogenin is in an evolutionarily conserved linkage group on human chromosome 1q31-q41 and unlinked to other mapped muscle regulatory factor genes', Genomics, vol. 8, no. 3, pp. 427-434. https://doi.org/10.1016/0888-7543(90)90028-S

@article{ea731ab387484253815b89865579a788,

title = "Myogenin is in an evolutionarily conserved linkage group on human chromosome 1q31-q41 and unlinked to other mapped muscle regulatory factor genes",

abstract = "Myogenin is a member of a family of muscle-specific regulatory factors which includes MyoD1, Myf-5, and Myf-6 (also called MRF4 and herculin). Extensive regions of sequence homology in genes for these three factors suggest duplication events associated with their evolution. In the present study, the chromosomal location of the myogenin gene in humans (MYOG), mice (Myog), and Chinese hamsters (MYOG) was determined using in situ hybridization to human metaphase chromosomes as well as segregation analysis among interspecific somatic cell hybrid panels and interspecific backcrossed mice. We localize the gene encoding myogenin to human chromosome 1q31-q41 within a linkage group homologous with a region on mouse chromosome 1 and Chinese hamster chromosome 5. The results verify the nonlinkage of MYOG to MYOD1, MYF5, and MYF6 genes and indicate that events associated with the duplication of MYOG with respect to MYOD1, MYF5, or MYF6 loci were not chromosome-wide.",

author = "E. Olson and D. Edmondson and Wright, {W. E.} and Lin, {V. K.} and Guenet, {J. L.} and D. Simon-Chazottes and Thompson, {L. H.} and Stallings, {R. L.} and Schroeder, {W. T.} and M. Duvic and D. Brock and D. Helin and Siciliano, {M. J.}",

note = "Funding Information: This work was supported in part by NIH Grants CA34936, AG01228, and HD39849 and awards from the Muscular Dystrophy Association, the Piton Foundation, the American Cancer Society, and Kenneth D. Muller to the University of Texas M. D. Anderson Cancer Center and performed in part under the auspices of the U.S. Department of Energy by the Lawrence Livermore National Laboratory under Contract W-7404-ENG48. E.O. is an Established Investigator of the American Heart Association. W.T.S. is a Roche-Squib Dermatology Foundation Fellow.",

year = "1990",

month = nov,

doi = "10.1016/0888-7543(90)90028-S",

language = "English (US)",

volume = "8",

pages = "427--434",

journal = "Genomics",

issn = "0888-7543",

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T1 - Myogenin is in an evolutionarily conserved linkage group on human chromosome 1q31-q41 and unlinked to other mapped muscle regulatory factor genes

AU - Olson, E.

AU - Edmondson, D.

AU - Wright, W. E.

AU - Lin, V. K.

AU - Guenet, J. L.

AU - Simon-Chazottes, D.

AU - Thompson, L. H.

AU - Stallings, R. L.

AU - Schroeder, W. T.

AU - Duvic, M.

AU - Brock, D.

AU - Helin, D.

AU - Siciliano, M. J.

N1 - Funding Information: This work was supported in part by NIH Grants CA34936, AG01228, and HD39849 and awards from the Muscular Dystrophy Association, the Piton Foundation, the American Cancer Society, and Kenneth D. Muller to the University of Texas M. D. Anderson Cancer Center and performed in part under the auspices of the U.S. Department of Energy by the Lawrence Livermore National Laboratory under Contract W-7404-ENG48. E.O. is an Established Investigator of the American Heart Association. W.T.S. is a Roche-Squib Dermatology Foundation Fellow.

PY - 1990/11

Y1 - 1990/11

N2 - Myogenin is a member of a family of muscle-specific regulatory factors which includes MyoD1, Myf-5, and Myf-6 (also called MRF4 and herculin). Extensive regions of sequence homology in genes for these three factors suggest duplication events associated with their evolution. In the present study, the chromosomal location of the myogenin gene in humans (MYOG), mice (Myog), and Chinese hamsters (MYOG) was determined using in situ hybridization to human metaphase chromosomes as well as segregation analysis among interspecific somatic cell hybrid panels and interspecific backcrossed mice. We localize the gene encoding myogenin to human chromosome 1q31-q41 within a linkage group homologous with a region on mouse chromosome 1 and Chinese hamster chromosome 5. The results verify the nonlinkage of MYOG to MYOD1, MYF5, and MYF6 genes and indicate that events associated with the duplication of MYOG with respect to MYOD1, MYF5, or MYF6 loci were not chromosome-wide.

AB - Myogenin is a member of a family of muscle-specific regulatory factors which includes MyoD1, Myf-5, and Myf-6 (also called MRF4 and herculin). Extensive regions of sequence homology in genes for these three factors suggest duplication events associated with their evolution. In the present study, the chromosomal location of the myogenin gene in humans (MYOG), mice (Myog), and Chinese hamsters (MYOG) was determined using in situ hybridization to human metaphase chromosomes as well as segregation analysis among interspecific somatic cell hybrid panels and interspecific backcrossed mice. We localize the gene encoding myogenin to human chromosome 1q31-q41 within a linkage group homologous with a region on mouse chromosome 1 and Chinese hamster chromosome 5. The results verify the nonlinkage of MYOG to MYOD1, MYF5, and MYF6 genes and indicate that events associated with the duplication of MYOG with respect to MYOD1, MYF5, or MYF6 loci were not chromosome-wide.

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ER -

Myogenin is in an evolutionarily conserved linkage group on human chromosome 1q31-q41 and unlinked to other mapped muscle regulatory factor genes

Abstract

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