TY - JOUR
T1 - Myocardial triglycerides and systolic function in humans
T2 - In vivo evaluation by localized proton spectroscopy and cardiac imaging
AU - Szczepaniak, Lidia S.
AU - Dobbins, Robert L.
AU - Metzger, Gregory J.
AU - Sartoni-D'Ambrosia, Greta
AU - Arbique, Debbie
AU - Vongpatanasin, Wanpen
AU - Unger, Roger
AU - Victor, Ronald G.
PY - 2003/3/1
Y1 - 2003/3/1
N2 - Recent experimental data suggest that adiposity directly damages the heart by promoting ectopic deposition of triglyceride, a process known as myocardial steatosis. The goal of this study was to develop and validate proton magnetic resonance spectroscopy (1H MRS) as an in vivo tool to measure myocardial lipid content. Complementary studies in rat tissue ex vivo and in 15 healthy humans in vivo provided evidence that 1H MRS constitutes a reproducible technique for the measurement of myocardial triglyceride. In myocardial tissue from Zucker rats, the 1H MRS measurement of triglyceride matched that obtained by biochemical measurement (P < 0.001). In human subjects triglyceride was evident in the hearts of even the very lean individuals and was elevated in overweight and obese subjects. Increased myocardial triglyceride content was accompanied by elevated LV mass and suppressed septal wall thickening as measured by cardiac imaging.
AB - Recent experimental data suggest that adiposity directly damages the heart by promoting ectopic deposition of triglyceride, a process known as myocardial steatosis. The goal of this study was to develop and validate proton magnetic resonance spectroscopy (1H MRS) as an in vivo tool to measure myocardial lipid content. Complementary studies in rat tissue ex vivo and in 15 healthy humans in vivo provided evidence that 1H MRS constitutes a reproducible technique for the measurement of myocardial triglyceride. In myocardial tissue from Zucker rats, the 1H MRS measurement of triglyceride matched that obtained by biochemical measurement (P < 0.001). In human subjects triglyceride was evident in the hearts of even the very lean individuals and was elevated in overweight and obese subjects. Increased myocardial triglyceride content was accompanied by elevated LV mass and suppressed septal wall thickening as measured by cardiac imaging.
KW - Cardiac imaging
KW - Left ventricular function
KW - Left ventricular mass
KW - Localized magnetic resonance spectroscopy
KW - Myocardial triglyceride
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U2 - 10.1002/mrm.10372
DO - 10.1002/mrm.10372
M3 - Article
C2 - 12594743
AN - SCOPUS:0037371754
SN - 0740-3194
VL - 49
SP - 417
EP - 423
JO - Magnetic Resonance in Medicine
JF - Magnetic Resonance in Medicine
IS - 3
ER -