Abstract
Objectives: Myeloid and lymphoid neoplasms with abnormalities of fibroblast growth factor receptor 1 gene (FGFR1) are a rare and aggressive disease group that harbors translocations of FGFR1 with at least 14 recognized partner genes. We report a case of a patient with a novel t(17;21)(p13;q22) with RUNX1 rearrangement and trilineage blasts. Methods: A 29-year-old man with relapsed T-lymphoblastic lymphoma in the cervical nodes showed a myeloproliferative neoplasm in his bone marrow with three separate populations of immunophenotypically aberrant myeloid, T-lymphoid, and B-lymphoid blasts by flow cytometry. Cytogenetic and fluorescent in situ hybridization studies showed unique dual translocations of t(8;13)(p11.2;q12) and t(17;21)(p13;q22) with RUNX1 rearrangement. Results: The patient was initiated on a mitoxantrone, etoposide, and cytarabine chemotherapy regimen and died of complications of disease 1 month later. Conclusions: To our knowledge, this is the first reported case of a myeloid and lymphoid neoplasm with abnormalities of FGFR1 with t(17;21)(p13;q22) and trilineage blasts.
Original language | English (US) |
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Pages (from-to) | 738-748 |
Number of pages | 11 |
Journal | American journal of clinical pathology |
Volume | 143 |
Issue number | 5 |
DOIs | |
State | Published - May 2015 |
Keywords
- Eosinophilia
- FGFR1
- Hematopoietic
- Lymphoid
- Myeloproliferative
- Neoplasm
- RUNX1
- ZMYM2
ASJC Scopus subject areas
- Pathology and Forensic Medicine