Myelodysplastic syndrome (MDS)-associated cytogenetic abnormalities in pediatric chronic myelogenous leukemia

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Chronic myelogenous leukemia (CML) is very rare in the pediatric population. We report the case of a 2-year-old female with CML and concurrent myelodysplastic syndrome (MDS) associated cytogenetic abnormalities. The co-existence of t(9;22) and chromosomal deletions that are associated with MDS poses a unique diagnostic challenge. Given the reported association of t(9;22) and genomic instability, we hypothesize that the chromosomal deletions represent clonal evolution of the CML. Pediatr Blood Cancer 2013;60:E146-E148.

Original languageEnglish (US)
Pages (from-to)E146-E148
JournalPediatric Blood and Cancer
Issue number11
StatePublished - Nov 2013


  • Chronic myelogenous leukemia
  • Cytogenetics
  • Molecular genetics
  • Myelodysplastic syndrome

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology


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