TY - JOUR
T1 - Mycoplasma pneumoniae induces host-dependent pulmonary inflammation and airway obstruction in mice
AU - Fonseca-Aten, Monica
AU - Ríos, Ana M.
AU - Mejías, Asunción
AU - Chávez-Bueno, Susana
AU - Katz, Kathy
AU - Gómez, Ana M.
AU - McCracken, George H.
AU - Hardy, R. Doug
PY - 2005/3
Y1 - 2005/3
N2 - Respiratory tract infections result in wheezing in a subset of patients. Mycoplasma pneumoniae is a common etiologic agent of acute respiratory infection in children and adults that has been associated with wheezing in 20-40% of individuals. The current study was undertaken to elucidate the host-dependent pulmonary and immunologic response to M. pneumoniae respiratory infection by studying mice with different immunogenetic backgrounds (BALB/c mice versus C57BL/6 mice). After M. pneumoniae infection, only BALB/c mice developed significant airway obstruction (AO) compared with controls. M. pneumoniae-infected BALB/c mice manifested significantly elevated airway hyperresponsiveness (AHR) compared with C57BL/6 mice 4 and 7 d after inoculation as well as BALB/c control mice. Compared with C57BL/6 mice, BALB/c mice developed worse pulmonary inflammation, including greater peribronchial infiltrates. Infected BALB/c mice had significantly higher concentrations of tumor necrosis factor-α, interferon-γ, interleukin (IL)-1β, IL-6, IL-12, KC (functional IL-8), and macrophage inflammatory protein 1α in the bronchoalveolar lavage fluid compared with infected C57BL/6 mice. No differences in IL-2, IL-4, IL-5, IL-10, and granulocyte/macrophage colony-stimulating factor concentrations were found. The mice in this study exhibited host-dependent infection-related AO and AHR associated with chemokine and T-helper type (Th)1 pulmonary host response and not Th2 response after M. pneumoniae infection.
AB - Respiratory tract infections result in wheezing in a subset of patients. Mycoplasma pneumoniae is a common etiologic agent of acute respiratory infection in children and adults that has been associated with wheezing in 20-40% of individuals. The current study was undertaken to elucidate the host-dependent pulmonary and immunologic response to M. pneumoniae respiratory infection by studying mice with different immunogenetic backgrounds (BALB/c mice versus C57BL/6 mice). After M. pneumoniae infection, only BALB/c mice developed significant airway obstruction (AO) compared with controls. M. pneumoniae-infected BALB/c mice manifested significantly elevated airway hyperresponsiveness (AHR) compared with C57BL/6 mice 4 and 7 d after inoculation as well as BALB/c control mice. Compared with C57BL/6 mice, BALB/c mice developed worse pulmonary inflammation, including greater peribronchial infiltrates. Infected BALB/c mice had significantly higher concentrations of tumor necrosis factor-α, interferon-γ, interleukin (IL)-1β, IL-6, IL-12, KC (functional IL-8), and macrophage inflammatory protein 1α in the bronchoalveolar lavage fluid compared with infected C57BL/6 mice. No differences in IL-2, IL-4, IL-5, IL-10, and granulocyte/macrophage colony-stimulating factor concentrations were found. The mice in this study exhibited host-dependent infection-related AO and AHR associated with chemokine and T-helper type (Th)1 pulmonary host response and not Th2 response after M. pneumoniae infection.
KW - Airway hyperresponsiveness
KW - Airway obstruction
KW - Asthma
KW - Chemokines
KW - Cytokines
KW - Mycoplasma pneumoniae
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U2 - 10.1165/rcmb.2004-0197OC
DO - 10.1165/rcmb.2004-0197OC
M3 - Article
C2 - 15626776
AN - SCOPUS:15044354160
SN - 1044-1549
VL - 32
SP - 201
EP - 210
JO - American journal of respiratory cell and molecular biology
JF - American journal of respiratory cell and molecular biology
IS - 3
ER -