Development of the male phenotype during embryogenesis requires the action of androgenic hormone from the fetal testis. Mutations that cause resistance to androgen action impair normal male differentiation and result in a spectrum of developmental and functional disorders. Analysis of such mutations in humans and animals has provided insight into the normal pathway of androgen action and into sexual differentiation.
|Original language||English (US)|
|Number of pages||5|
|Journal||Trends in Genetics|
|State||Published - 1985|
ASJC Scopus subject areas