Mutations of G(sα) designed to alter the reactivity of the protein with bacterial toxins. Substitutions at Arg¹⁸⁷ results in loss of GTPase activity

Medicine & Life Sciences

• Bacterial Toxins 90%
• GTP Phosphohydrolases 75%
• Guanosine Triphosphate 70%
• Adenylyl Cyclases 50%
• Cholera Toxin 39%
• Pertussis Toxin 37%
• Mutation 37%
• Hydrolysis 30%
• Proteins 24%
• Adenosine Diphosphate Ribose 24%
• ADP-Ribosylation 22%
• Mutant Proteins 17%
• GTP-Binding Proteins 16%
• Arginine 15%
• Carrier Proteins 14%
• Complementary DNA 13%
• Cell Membrane 12%
• Peptides 10%

Chemical Compounds

• Bacterial Toxin 100%
• Mutation 56%
• Toxin 42%
• Substitution Reaction 41%
• Protein 27%
• Glu-Ala 18%
• GDP 14%
• Hydrolysis 13%
• Arginine Residue 13%
• Guanine 10%
• Polypeptide 9%
• Dissociation 7%