Multiple depressive episodes and plasma postdexamethasone cortisol levels

James H. Meador-Woodruff, George Gurguis, Leon Grunhaus, Roger F. Haskett, John F. Greden

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


The hypothalamic-pituitary-adrenal (HPA) axis is dysregulated in many patients with major depressive disorder (MDD). To determine whether or not a past history of depressive episodes is associated with this dysregulation, we studied the relationships among number of past depressive episodes, number of previous hospitalizations for depression, and number of years since first depressive episode and biological markers of depression (postdexamethasone plasma cortisol levels and dexamethasone suppressor/nonsuppressor status). No significant relationships were detected.

Original languageEnglish (US)
Pages (from-to)583-592
Number of pages10
JournalBiological Psychiatry
Issue number5
StatePublished - May 1987

ASJC Scopus subject areas

  • Biological Psychiatry


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