Multiple Cerebral Microbleeds: MRI Marker of a Diffuse Hemorrhage-Prone State

Julio A. Chalela, Dong Wha Kang, Steven Warach

Research output: Contribution to journalArticlepeer-review

59 Scopus citations


Background. Recent reports have indicated that cerebral microbleeds (CMBs) detected on gradient-echo (GRE) magnetic resonance imaging may be a risk factor for therapy-related intracranial hemorrhages (ICHs). Case Description. The authors describe 3 patients with multiple CMBs in whom ICHs occurred either after tissue plasminogen activator administration or after the initiation of antiplatelet therapy. Hemorrhages occurred in brain areas with normal appearances on GRE imaging and remote from the CMBs. Conclusion. Multiple CMBs may signal a diffuse hemorrhage-prone vasculopathy.

Original languageEnglish (US)
Pages (from-to)54-57
Number of pages4
JournalJournal of Neuroimaging
Issue number1
StatePublished - Jan 2004


  • Gradient-echo imaging
  • Hemorrhage risk
  • Microbleeds

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology


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