Multiparametric radiomics for predicting the aggressiveness of papillary thyroid carcinoma using hyperspectral images

Ka'Toria Edwards, Martin Halicek, James V. Little, Amy Y. Chen, Baowei Fei

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations


Papillary thyroid carcinoma (PTC) is primarily treated by surgical resection. During surgery, surgeons often need intraoperative frozen analysis and pathologic consultation in order to detect PTC. In some cases pathologists cannot determine if the tumor is aggressive until the operation has been completed. In this work, we have taken tumor classification a step further by determining the tumor aggressiveness of fresh surgical specimens. We employed hyperspectral imaging (HSI) in combination with multiparametric radiomic features to complete this task. The study cohort includes 72 ex-vivo tissue specimens from 44 patients with pathology-confirmed PTC. A total of 67 features were extracted from this data. Using machine learning classification methods, we were able to achieve an AUC of 0.85. Our study shows that hyperspectral imaging and multiparametric radiomic features could aid in the pathological detection of tumor aggressiveness using fresh surgical spemens obtained during surgery.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2021
Subtitle of host publicationComputer-Aided Diagnosis
EditorsMaciej A. Mazurowski, Karen Drukker
ISBN (Electronic)9781510640238
StatePublished - 2021
EventMedical Imaging 2021: Computer-Aided Diagnosis - Virtual, Online, United States
Duration: Feb 15 2021Feb 19 2021

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceMedical Imaging 2021: Computer-Aided Diagnosis
Country/TerritoryUnited States
CityVirtual, Online


  • Cancer
  • Head
  • Hyperspectral Imaging
  • Neck
  • Radiomics
  • Tissues
  • Tumor Aggression

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Multiparametric radiomics for predicting the aggressiveness of papillary thyroid carcinoma using hyperspectral images'. Together they form a unique fingerprint.

Cite this