Multiparametric MR mapping in clinical decision-making for diffuse liver disease

Helena B. Thomaides-Brears, Rita Lepe, Rajarshi Banerjee, Carlos Duncker

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Accurate diagnosis, monitoring and treatment decisions in patients with chronic liver disease currently rely on biopsy as the diagnostic gold standard, and this has constrained early detection and management of diseases that are both varied and can be concurrent. Recent developments in multiparametric magnetic resonance imaging (mpMRI) suggest real potential to bridge the diagnostic gap between non-specific blood-based biomarkers and invasive and variable histological diagnosis. This has implications for the clinical care and treatment pathway in a number of chronic liver diseases, such as haemochromatosis, steatohepatitis and autoimmune or viral hepatitis. Here we review the relevant MRI techniques in clinical use and their limitations and describe recent potential applications in various liver diseases. We exemplify case studies that highlight how these techniques can improve clinical practice. These techniques could allow clinicians to increase their arsenals available to utilise on patients and direct appropriate treatments.

Original languageEnglish (US)
Pages (from-to)3507-3522
Number of pages16
JournalAbdominal Radiology
Issue number11
StatePublished - Nov 1 2020
Externally publishedYes


  • cT1
  • Diffusion-weighted imaging
  • Elastography
  • Multiparametric magnetic resonance imaging
  • PDFF
  • T2*

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Gastroenterology
  • Urology


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