TY - JOUR
T1 - Multicenter AIDS Cohort Study Quantitative Coronary Plaque Progression Study
T2 - Rationale and design
AU - Nakanishi, Rine
AU - Post, Wendy S.
AU - Osawa, Kazuhiro
AU - Jayawardena, Eranthi
AU - Kim, Michael
AU - Sheidaee, Nasim
AU - Nezarat, Negin
AU - Rahmani, Sina
AU - Kim, Nicholas
AU - Hathiramani, Nicolai
AU - Susarla, Shriraj
AU - Palella, Frank
AU - Witt, Mallory
AU - Blaha, Michael J.
AU - Brown, Todd T.
AU - Kingsley, Lawrence
AU - Haberlen, Sabina A.
AU - Dailing, Christopher
AU - Budoff, Matthew J.
N1 - Funding Information:
Dr Matthew Budoff receives grant support from General Electric; Dr Palella is a consultant and Speakers Bureau for Gilead Sciences, Janssen Pharmaceuticals, Merck and Bristol Myers Squibb; Dr Jacobson receives grant support from National Institute of Health; Dr Post receives grant support from National Institute of Health. For the remaining authors there are no conflicts of interest.
Funding Information:
This study was funded by the National Heart, Lung, and Blood Institute (R01 HL095129 and R01HL125053 to Dr Post), with additional support from the National Center for Advancing Translational Sciences, a component of the National Institutes of Health and National Institutes of Health Roadmap for Medical Research (grant UL1 RR 025005). The MACS is funded by the National Institute of Allergy and Infectious Disease, with additional supplemental funding from the National Cancer Institute (grants UO1-AI-35042, UL1-RR025005, UM1-AI-35043, UO1-AI-35039, UO1-AI-3540, and UO1-AI-35041).
Publisher Copyright:
Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2018
Y1 - 2018
N2 - Background and aim The association of HIV with coronary atherosclerosis has been established; however, the progression of coronary atherosclerosis over time among participants with HIV is not well known. The Multicenter AIDS Cohort Study Quantitative Coronary Plaque Progression Study is a large prospective multicenter study quantifying progression of coronary plaque assessed by serial coronary computed tomography angiography (CTA). Patients and methods HIV-infected and uninfected men who were enrolled in the Multicenter AIDS Cohort Study Cardiovascular Substudy were eligible to complete a follow-up contrast coronary CTA 3-6 years after baseline. We measured coronary plaque volume and characteristics (calcified and noncalcified plaque including fibrous, fibrous-fatty, and low attenuation) and vulnerable plaque among HIV-infected and uninfected men using semiautomated plaque software to investigate the progression of coronary atherosclerosis over time. Conclusion We describe a novel, large prospective multicenter study investigating incidence, transition of characteristics, and progression in coronary atherosclerosis quantitatively assessed by serial coronary CTAs among HIV-infected and uninfected men.
AB - Background and aim The association of HIV with coronary atherosclerosis has been established; however, the progression of coronary atherosclerosis over time among participants with HIV is not well known. The Multicenter AIDS Cohort Study Quantitative Coronary Plaque Progression Study is a large prospective multicenter study quantifying progression of coronary plaque assessed by serial coronary computed tomography angiography (CTA). Patients and methods HIV-infected and uninfected men who were enrolled in the Multicenter AIDS Cohort Study Cardiovascular Substudy were eligible to complete a follow-up contrast coronary CTA 3-6 years after baseline. We measured coronary plaque volume and characteristics (calcified and noncalcified plaque including fibrous, fibrous-fatty, and low attenuation) and vulnerable plaque among HIV-infected and uninfected men using semiautomated plaque software to investigate the progression of coronary atherosclerosis over time. Conclusion We describe a novel, large prospective multicenter study investigating incidence, transition of characteristics, and progression in coronary atherosclerosis quantitatively assessed by serial coronary CTAs among HIV-infected and uninfected men.
KW - HIV
KW - coronary artery disease
KW - coronary computed tomographic angiography
KW - plaque progression
KW - vulnerable plaque
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U2 - 10.1097/MCA.0000000000000546
DO - 10.1097/MCA.0000000000000546
M3 - Article
C2 - 28777120
AN - SCOPUS:85038817785
SN - 0954-6928
VL - 29
SP - 23
EP - 29
JO - Coronary artery disease
JF - Coronary artery disease
IS - 1
ER -