TY - JOUR
T1 - Multiallergen nasal challenges in nonallergic rhinitis
AU - Wierzbicki, Dania A.
AU - Majmundar, Amee R.
AU - Schull, Diane E.
AU - Khan, David A.
N1 - Funding Information:
Funding Source: This study was supported by the Division of Allergy and Immunology, University of Texas Southwestern Medical Center.
PY - 2008/6
Y1 - 2008/6
N2 - Background: It has been proposed that some patients with nonallergic rhinitis may have "localized allergy" of the nasal mucosa. Nasal challenges with aeroallergens can help determine whether a patient is clinically allergic via an IgE-mediated pathway. Objective: To determine the prevalence of localized allergy in patients with negative skin prick test results via nasal challenges with an array of allergens. Methods: Twenty individuals with perennial rhinitis and negative epicutaneous test results to common perennial aeroallergens underwent nasal challenges to glycerin, Alternaria, cockroach, timothy grass, cat hair, and Dermatophagoides pteronyssinus. Total symptom scores, peak nasal inspiratory flow rates, and nasal eosinophil counts were determined. Results: Of 20 patients with nonallergic rhinitis, 4 were hyperresponsive to glycerin and were not subsequently challenged. Eleven patients had negative nasal challenges. Five patients developed positive challenges (total symptom score ≥5) to 7 allergens. These 5 patients returned for nasal provocation testing to their offending allergens, and these repeated challenges were negative. Three control subjects with allergic rhinitis developed positive challenges after nasal allergen challenge. Conclusions: Although some individuals with nonallergic rhinitis can have positive nasal allergen challenges, these results were not reproducible in the present patient population.
AB - Background: It has been proposed that some patients with nonallergic rhinitis may have "localized allergy" of the nasal mucosa. Nasal challenges with aeroallergens can help determine whether a patient is clinically allergic via an IgE-mediated pathway. Objective: To determine the prevalence of localized allergy in patients with negative skin prick test results via nasal challenges with an array of allergens. Methods: Twenty individuals with perennial rhinitis and negative epicutaneous test results to common perennial aeroallergens underwent nasal challenges to glycerin, Alternaria, cockroach, timothy grass, cat hair, and Dermatophagoides pteronyssinus. Total symptom scores, peak nasal inspiratory flow rates, and nasal eosinophil counts were determined. Results: Of 20 patients with nonallergic rhinitis, 4 were hyperresponsive to glycerin and were not subsequently challenged. Eleven patients had negative nasal challenges. Five patients developed positive challenges (total symptom score ≥5) to 7 allergens. These 5 patients returned for nasal provocation testing to their offending allergens, and these repeated challenges were negative. Three control subjects with allergic rhinitis developed positive challenges after nasal allergen challenge. Conclusions: Although some individuals with nonallergic rhinitis can have positive nasal allergen challenges, these results were not reproducible in the present patient population.
UR - http://www.scopus.com/inward/record.url?scp=45149109628&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=45149109628&partnerID=8YFLogxK
U2 - 10.1016/S1081-1206(10)60051-8
DO - 10.1016/S1081-1206(10)60051-8
M3 - Article
C2 - 18592815
AN - SCOPUS:45149109628
SN - 1081-1206
VL - 100
SP - 533
EP - 537
JO - Annals of Allergy, Asthma and Immunology
JF - Annals of Allergy, Asthma and Immunology
IS - 6
ER -